Case report

World Journal of Surgical Oncology

, 10:185

Open Access This content is freely available online to anyone, anywhere at any time.

Presentation of two patients with malignant granulosa cell tumors, with a review of the literature

  • Ryousuke TamuraAffiliated withDepartment of Obstetrics and Gynecology, Hirosaki University Graduate School of Medicine
  • , Yoshihito YokoyamaAffiliated withDepartment of Obstetrics and Gynecology, Hirosaki University Graduate School of Medicine Email author 
  • , Takeshi YanagitaAffiliated withDepartment of Obstetrics and Gynecology, Hirosaki University Graduate School of Medicine
  • , Yukiko MatsumuraAffiliated withDepartment of Obstetrics and Gynecology, Hirosaki University Graduate School of Medicine
  • , Kazuhiro AbeAffiliated withDepartment of Obstetrics and Gynecology, Hirosaki University Graduate School of Medicine
  • , Ryousuke TaniguchiAffiliated withDepartment of Obstetrics and Gynecology, Hirosaki University Graduate School of Medicine
  • , Hideki MizunumaAffiliated withDepartment of Obstetrics and Gynecology, Hirosaki University Graduate School of Medicine

Abstract

Granulosa cell tumors (GCTs) of the ovary account for 2 to 5 of ovarian malignancies. We present two patients with malignant ovarian adult GCT. In one patient, a combination of bleomycin, etoposide, and cisplatin was effective after initial surgery for malignant GCT. In the other, an aromatase inhibitor was effective for recurrent malignant GCT. We also review the literature for further management of this tumor. Because GCT of the ovary is rare, it will be necessary to elucidate the clinical phenotype and establish treatment protocols by accumulating and analyzing more patients.

Keywords

Ovarian malignant granulosa cell tumor BEP combination therapy Aromatase inhibitor