Molecular epidemiology, prenatal exposure and prevention of cancer
- Frederica Perera
- … show all 1 hide
Molecular Epidemiology was originally conceived as a preventive approach, providing a valuable tool for investigating risk factors for cancer in vulnerable populations. Biomarkers can be used as early indicators of risk for preventative purposes and risk assessment. The present contribution mainly refers to in utero exposures to carcinogens, since humans are especially vulnerable during fetal development. Environmental exposures in utero can increase risks for both childhood and adult cancers; their interactions with genetic and nutritional susceptibility factors may further increase risk. Thus, the early developmental period represents an important window for cancer prevention.
- Jirtle RL, Skinner MK: Environmental epigenomics and disease susceptibility. Nat Rev Genet 2007, 8 (4) : 253–262. CrossRef
- Buffler PA, Kwan ML, Reynolds P, Urayama KY: Environmental and genetic risk factors for childhood leukemia: appraising the evidence. Cancer Invest 2005, 23 (1) : 60–75.
- Smith MT, McHale CM, Wiemels JL, Zhang L, Wiencke JK, Zheng S, Gunn L, Skibola CF, Ma X, Buffler PA: Molecular biomarkers for the study of childhood leukemia. Toxicol Appl Pharmacol 2005, 206 (2) : 237–245. CrossRef
- Shu XO, Perentesis JP, Wen W, Buckley JD, Boyle E, Ross JA, Robison LL: Parental exposure to medications and hydrocarbons and ras mutations in children with acute lymphoblastic leukemia: a report from the Children's Oncology Group. Cancer Epidemiol Biomarkers Prev 2004, 13 (7) : 1230–1235.
- Sinnett D, Krajinovic M, Labuda D: Genetic susceptibility to childhood acute lymphoblastic leukemia. Leuk Lymphoma 2000, 38 (5–6) : 447–462. CrossRef
- Ross JA, Swensen AR: Prenatal epidemiology of pediatric tumors. Current oncology reports 2000, 2 (3) : 234–241. CrossRef
- Ma X, Buffler PA, Gunier RB, Dahl G, Smith MT, Reinier K, Reynolds P: Critical windows of exposure to household pesticides and risk of childhood leukemia. Environmental health perspectives 2002, 110 (9) : 955–960. CrossRef
- Perera F, Schneider A, Herbstman J: Prenatal Environmental Exposures, Epigenetics, and Disease. Reprod Toxicol 2010, in press.
- Perera FP, Rauh V, Tsai WY, Kinney P, Camann D, Barr D, Bernert T, Garfinkel R, Tu YH, Diaz D, et al.: Effects of transplacental exposure to environmental pollutants on birth outcomes in a multi-ethnic population. Environ Health Perspect 2003, 111 (2) : 201–205. CrossRef
- Perera F, Tang D, Whyatt R, Lederman SA, Jedrychowski W: DNA damage from polycyclic aromatic hydrocarbons measured by benzo[a]pyrene-DNA adducts in mothers and newborns from Northern Manhattan, the World Trade Center Area, Poland, and China. Cancer Epidemiol Biomarkers Prev 2005, 14 (3) : 709–714. CrossRef
- Perera FP, Rauh V, Whyatt RM, Tang D, Tsai WY, Bernert JT, Tu YH, Andrews H, Barr DB, Camann DE, et al.: A summary of recent findings on birth outcomes and developmental effects of prenatal ETS, PAH, and pesticide exposures. Neurotoxicology 2005, 26 (4) : 573–587. CrossRef
- Bocskay KA, Tang D, Orjuela MA, Xinhua L, Warburton DP, Perera FP: Chromosomal aberrations in cord blood are associated with prenatal exposure to carcinogenic polycyclic aromatic hydrocarbons. Cancer Epidemiol Biomarkers Prev 2005, 14 (2) : 506–511. CrossRef
- Orjuela MA, Liu X, Warburton D, Siebert AL, Cujar CP, Tang D, Jobanputra V, Perera FP: Prenatal PAH Exposure Is Associated with Chromosome-specific Aberrations in Cord Blood. Mutation Research/Genetic Toxicology and Environmental Mutagenesis 2010. Submitted
- Rodenhiser D, Mann M: Epigenetics and human disease: translating basic biology into clinical applications. CMAJ 2006, 174 (3) : 341–348.
- Belinsky SA, Liechty KC, Gentry FD, Wolf HJ, Rogers J, Vu K, Haney J, Kennedy TC, Hirsch FR, Miller Y, et al.: Promoter hypermethylation of multiple genes in sputum precedes lung cancer incidence in a high-risk cohort. Cancer Res 2006, 66 (6) : 3338–3344. CrossRef
- Reik W: Stability and flexibility of epigenetic gene regulation in mammalian development. Nature 2007, 447 (7143) : 425–432. CrossRef
- Edwards TM, Myers JP: Environmental exposures and gene regulation in disease etiology. Environmental health perspectives 2007, 115 (9) : 1264–1270. CrossRef
- Tretyakova N, Guza R, Matter B: Endogenous cytosine methylation and the formation of carcinogen carcinogen-DNA adducts. Nucleic acids symposium series (2004) 2008, (52) : 49–50.
- Perera F, Tang WY, Herbstman J, Tang D, Levin L, Miller R, Ho SM: Relation of DNA methylation of 5'-CpG island of ACSL3 to transplacental exposure to airborne polycyclic aromatic hydrocarbons and childhood asthma. PLoS ONE 2009, 4 (2) : e4488. CrossRef
- Molecular epidemiology, prenatal exposure and prevention of cancer
- Open Access
- Available under Open Access This content is freely available online to anyone, anywhere at any time.
- Online Date
- April 2011
- Online ISSN
- BioMed Central
- Additional Links
- Frederica Perera (1)
- Author Affiliations
- 1. Mailman School of Public Health, Columbia University, 100 Haven Avenue, Tower 3, #25F, 10032, New York, NY, USA