Research

Nutrition Journal

, 11:91

First online:

Open Access This content is freely available online to anyone, anywhere at any time.

Dietary total antioxidant capacity from different assays in relation to serum C-reactive protein among young Japanese women

  • Satomi KobayashiAffiliated withDepartment of Social and Preventive Epidemiology, Graduate School of Medicine, the University of Tokyo
  • , Kentaro MurakamiAffiliated withDepartment of Social and Preventive Epidemiology, School of Public Health, the University of Tokyo
  • , Satoshi SasakiAffiliated withDepartment of Social and Preventive Epidemiology, Graduate School of Medicine, the University of TokyoDepartment of Social and Preventive Epidemiology, School of Public Health, the University of Tokyo Email author 
  • , Kazuhiro UenishiAffiliated withLaboratory of Physiological Nutrition, Kagawa Nutrition University
  • , Mitsuyo YamasakiAffiliated withDepartment of Health and Nutrition Science, Faculty of Health and Social Welfare Science, Nishikyushu University
  • , Hitomi HayabuchiAffiliated withDepartment of Human Environmental Science, Fukuoka Women’s University
  • , Toshinao GodaAffiliated withDepartment of Nutrition, School of Food and Nutritional Sciences, University of Shizuoka
  • , Jun OkaAffiliated withDepartment of Nutrition, Faculty of Home Economics, Tokyo Kasei University
  • , Keiko BabaAffiliated withDepartment of Kids Culture Design Center, Mie Chukyo University
    • , Kazuko OhkiAffiliated withGraduate School of Science for Living System, Showa Women’s University
    • , Reiko WatanabeAffiliated withDepartment of Health and Nutrition, University of Niigata Prefecture
    • , Yoshiko SugiyamamaAffiliated withDepartment of Nutrition Management, Faculty of Health and Nutrition, Minami Kyushu University

Abstract

Background

The association between dietary total antioxidant capacity (TAC) from different assays and serum C-reactive protein (CRP) has not been assessed in non-Western populations. We examined the association between dietary TAC and serum CRP concentration in young Japanese women using different four TAC assays.

Methods

The subjects were 443 young Japanese women aged 18–22 years. Dietary TAC was assessed with a self-administered diet history questionnaire and the TAC value of each food using the following four assays: ferric reducing ability of plasma (FRAP); oxygen radical absorbance capacity (ORAC); Trolox equivalent antioxidant capacity (TEAC); and total radical-trapping antioxidant parameter (TRAP). Serum CRP concentrations were measured by highly sensitive nephelometry.

Results

The major contributor to dietary TAC was green, barley, and oolong tea (FRAP: 53%, ORAC: 45%, TEAC: 36%, and TRAP: 44%). The prevalence of elevated CRP concentrations (≥ 1 mg/L) was 5.6%. TAC from FRAP was inversely associated with serum CRP concentrations (adjusted odds ratio [OR] for elevated CRP concentration in high [compared with low] dietary TAC group: 0.39 [95% confidence interval (CI): 0.16-0.98]; P = 0.04). TAC from ORAC was inversely associated with CRP, although the association was not significant (OR: 0.48 [95% CI: 0.20-1.14]; P = 0.10). TAC from TEAC was inversely associated with CRP (OR: 0.32 [95% CI: 0.12-0.82]; P = 0.02), as was TAC from TRAP (OR: 0.31 [95% CI: 0.12-0.81]; P = 0.02).

Conclusions

Dietary TAC was inversely associated with serum CRP concentration in young Japanese women regardless of assay. Further studies are needed in other populations to confirm these results.

Keywords

Dietary total antioxidant capacity Serum C-reactive protein Diet history questionnaire Young Japanese women Epidemiology