Abstract
The anti-inflammatory activity of the aqueous extract of Chromolaena odorata was investigated in rats using the carrageenan-induced oedema, cotton pellet granuloma and formalin-induced oedema methods. The extract was administered orally at doses of 25, 50, 100 and 200 mg/kg. In the carrageenan method the paw oedema was significantly reduced by all the doses of the extract administered, with the 200 mg/kg dose producing the highest oedema inhibition (80.5%). In the cotton pellet method, granuloma weight was significantly reduced from 14 ± 0.1 to 9.0 ± 0.1 mg, while in the formaldehyde induced arthritis the extract inhibited the oedema during the 10-day period. In conclusion, this study has established the anti-inflammatory activity of C. odorata and, thus, justifies the traditional uses of the plant in the treatment of wounds and inflammation.
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Owoyele, V.B., Adediji, J.O. & Soladoye, A.O. Anti-inflammatory activity of aqueous leaf extract of Chromolaena odorata . Inflammopharmacol 13, 479–484 (2005). https://doi.org/10.1163/156856005774649386
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DOI: https://doi.org/10.1163/156856005774649386