The European Physical Journal Special Topics

, Volume 153, Issue 1, pp 353–356

Photoacoustic Spectroscopy to determine in vitro the non radiative relaxation time of protoporphyrin IX solution containing gold metallic nanoparticles

Authors

    • CICATA-IPN, Legaria 694, Col. Irrigación, 11500 México
  • A. Cruz-Orea
    • Departamento de Física
  • E. Ramón-Gallegos
    • Morphologia DepartamentEnvironment Citopathology Laboratory
  • R. Gutierrez Fuentes
    • CICATA-IPN, Legaria 694, Col. Irrigación, 11500 México
  • J. F. Sanchez Ramirez
    • CICATA-IPN, Legaria 694, Col. Irrigación, 11500 México
Article

DOI: 10.1140/epjst/e2008-00460-2

Cite this article as:
Jiménez Pérez, J., Cruz-Orea, A., Ramón-Gallegos, E. et al. Eur. Phys. J. Spec. Top. (2008) 153: 353. doi:10.1140/epjst/e2008-00460-2

Abstract.

In order to compare the non radiative relaxation time (NRRT) between standard protoporphyrin IX (PpIX) and protoporphyrin PpIX(1) solution containing gold metallic nanoparticles, we measured the photoacoustic spectroscopy (PAS) signal phase to determine, for each solution, the NRRT by using the Rosencwaig-Gesho theory, modified to include the effect of a finite non radiative deexcitation time. A NRRT average value, obtained for each solution, is reported and compared with some NRRT of triplet states reported in the literature for molecules with the same tetrapyrrolic structure. In the study was used PpIX disodium salt (DS) solution of 25% HCL. From each solution it was obtained its optical absorption spectrum, by using a UV-Vis spectrophotometer. After this, in the maximum observed optical absorption peak (404 nm), it was obtained the Photoacoustic (PA) signal phase as a function of the light modulation frequency, from 17 to 80 Hz. Our investigations are devoted to the improvement of the thermal treatments of drugs for medical applications.

Copyright information

© EDP Sciences/Società Italiana di Fisica/Springer-Verlag 2008