Biology Bulletin Reviews

, 1:390

Morphofunctional fundamentals for peptide regulation of aging

  • V. Kh. Khavinson
  • N. S. Lin’kova
  • A. V. Trofimov
  • V. O. Polyakova
  • N. N. Sevost’yanova
  • I. M. Kvetnoy
Proceedings of Contemporary Biology

DOI: 10.1134/S2079086411040025

Cite this article as:
Khavinson, V.K., Lin’kova, N.S., Trofimov, A.V. et al. Biol Bull Rev (2011) 1: 390. doi:10.1134/S2079086411040025

Abstract

Processes of aging related to different morphological and functional changes due to pathological or compensatory reactions are considered. Long-term studies of the use of peptide bioregulators showed their efficiency in the prophylaxis and treatment of pathologies characteristic for aged persons. The basis of the geroprotective action of peptides is revealed to be their capacity for active protein synthesis at the molecular level, cytodifferentiation activation, and proliferation on the cell level. At the same time, they prevent the development of mitochondrial apoptosis and at tissue level restore morphofunctional interactions that are weakened in aging.

Keywords

peptides protein synthesis differentiation proliferation apoptosis aging 

Copyright information

© Pleiades Publishing, Ltd. 2011

Authors and Affiliations

  • V. Kh. Khavinson
    • 1
  • N. S. Lin’kova
    • 1
  • A. V. Trofimov
    • 1
  • V. O. Polyakova
    • 1
  • N. N. Sevost’yanova
    • 1
  • I. M. Kvetnoy
    • 1
  1. 1.Institute of Bioregulation and GerontologyRussian Academy of Medical SciencesSt. PetersburgRussia

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