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Age-related molecular aspects of immunomodulating activity of peptides in the spleen

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Abstract

In this work, it was shown that short peptides, such as vilon, thymogen, crystagen and R-1, possess different age-associated immunoprotecting properties in the spleen. Both the R-1 and vilon peptides were found to activate T-helper cells. T-Helper activation by vilon was based on the inhibition of cellular apoptosis, whereas R-1 acted through positive stimulation of cellular proliferation and differentiation. Thymogen was found to be an activator of B-lymphocytes and acted through the inhibition of apoptosis, as well as by the stimulation of spleen cells proliferation. Crystagen was also found to activate the B-cell immunity system but had no effect on the processes of cellular renewal in the spleen during aging.

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Authors and Affiliations

  1. Saint-Petersburg Institute of Bioregulation and Gerontology, pr. Dinamo 3, St. Petersburg, 197110, Russia

    N. A. Chervyakova, N. S. Lin’kova, E. A. Kontsevaya, S. V. Trofimova & V. Kh. Khavinson

  2. Pavlov Institute of Physiology, Russian Academy of Sciences, nab. Makarova 6, St. Petersburg, 199034, Russia

    N. I. Chalisova & V. Kh. Khavinson

Authors
  1. N. A. Chervyakova
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  2. N. S. Lin’kova
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  3. N. I. Chalisova
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  4. E. A. Kontsevaya
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  5. S. V. Trofimova
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  6. V. Kh. Khavinson
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Corresponding author

Correspondence to N. A. Chervyakova.

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Original Russian Text © N.A. Chervyakova, N.S. Lin’kova, N.I. Chalisova, E.A. Kontsevaya, S.V. Trofimova, V.Kh. Khavinson, 2013, published in Uspekhi Gerontologii, 2013, Vol. 26, No. 2, pp. 224–228.

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Chervyakova, N.A., Lin’kova, N.S., Chalisova, N.I. et al. Age-related molecular aspects of immunomodulating activity of peptides in the spleen. Adv Gerontol 4, 12–15 (2014). https://doi.org/10.1134/S2079057014010020

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