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Comparative effects of difluoromethylornithine and siberian ginseng root tincture on radiation-induced carcinogenesis in rats and their lifespan

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Abstract

The effects of α-difluoromethylornithine (DFMO) and Siberian ginseng root tincture (SGRT) on radiation-induced carcinogenesis in rats and their lifespan have been studied. It has been shown that both DFMO and SGRT increased the survival rate as well as decreased the rate and multiplicity of malignant and benign tumors in irradiated rats. The beneficial effect of DFMO on the survival rate and its anticarcinogenic action are more pronounced than SGRT.

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Authors and Affiliations

  1. N.N. Petrov Research Institute of Oncology, ul. Leningradskaya 68, Pesochnyi, St. Petersburg, 197758, Russia

    V. G. Bespalov, V. A. Aleksandrov & A. L. Semenov

  2. Russian Scientific Center of Radiology and Surgical Technologies, ul. Leningradskaya 70, Pesochnyi, St. Petersburg, 197758, Russia

    A. L. Semenov, E. G. Kovan’ko & S. D. Ivanov

Authors
  1. V. G. Bespalov
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  2. V. A. Aleksandrov
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  3. A. L. Semenov
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  4. E. G. Kovan’ko
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  5. S. D. Ivanov
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Corresponding author

Correspondence to V. G. Bespalov.

Additional information

Original Russian Text © V.G. Bespalov, V.A. Aleksandrov, A.L. Semenov, E.G. Kovan’ko, S.D. Ivanov, 2012, published in Uspekhi Gerontologii, 2012, Vol. 25, No. 2, pp. 293–300.

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Bespalov, V.G., Aleksandrov, V.A., Semenov, A.L. et al. Comparative effects of difluoromethylornithine and siberian ginseng root tincture on radiation-induced carcinogenesis in rats and their lifespan. Adv Gerontol 3, 70–76 (2013). https://doi.org/10.1134/S2079057013010049

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