Skip to main content
SpringerLink
Log in

Age-related and clinicopathological features of colorectal cancer associated with K-ras gene status

  • Published:
Advances in Gerontology Aims and scope Submit manuscript

Abstract

Most human tumors, including colon-cancer tumors, develop in elderly people. One of the significant mutations that cause the development of malignant colon tumors is an activating mutation in the K-ras oncogene. The present study reports the results of a frequency analysis for this mutation in different age groups of colorectal cancer patients in northwest Russia and the connection between this mutation and the most significant clinical factors.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Gar’kavtseva, R.F., Amosenko, F.A., and Kalinin, V.I., Analysis of Somatic Mutations of gene K-ras at Adenocarcinoma of the Colon and Pancreas, Vestn. Ros. Nauch. Tsentra im. N.N. Blokhina, 2005, vol. 3, no. 4, pp. 16–23.

    Google Scholar 

  2. Dil’man, V.M., Endokrinologicheskaya onkologiya (Endocrinological Oncology), Leningrad: Meditsina, 1974.

    Google Scholar 

  3. Zaridze, D.G., Epidemiological Study of Morphogenetic Relationship between Adenoma and Colon Cancer, Arkh. Pat., 1987, no. 12, pp. 25–31.

  4. Imyanitov, E.N., Kalinovskii, V.P., Knyazev, P.G., et al., Molecular Genetics of Human Tumor, Vopr. Onkol., 1997, vol. 43, no. 1, pp. 95–101.

    Google Scholar 

  5. Imyanitov, E.N., Clinical and Molecular Aspects of Colorectal Cancer: Etiopathogenesis, Prophylactics and Individual Approach to the Therapy, Praktich. Onkol., 2005, vol. 6, no. 2, pp. 65–70.

    Google Scholar 

  6. Imyanitov, E.N. and Khanson, K.P., Molekulyarnaya onkologiya: klinicheskie aspekty (Molecular Oncology: Clinical Aspects), St. Petersburg: MAPO, 2007.

    Google Scholar 

  7. Kantserogenez (Carcinogenesis), Zaridze, D.G., Ed., Moscow: Meditsina, 2004.

    Google Scholar 

  8. Martynyuk, V.V., The Colon Cancer (Morbidity, Mortality, Risk Factors and Screening), in Prakticheskaya onkologiya: Izbr. lektsii (Practical Oncology: Selective Studies), St. Petersburg, 2004.

  9. Mel’nikov, R.A., Kovalev, V.A., Pravosudov, I.V., et al., Polyps and the Colon Cancer, Khirurgiya, 1989, no. 5, pp. 101–102.

  10. Merabishvili, V.M., Zlokachestvennye novoobrazovaniya v mire, Rossii, Sankt-Peterburge (Malignant Neoplasms in Patients of the World, Russia and St. Petersburg), St. Petersburg, 2007.

  11. Prorokov, V.V., Malikhov, A.G., and Knysh, V.I., Contemporary Principles of Diagnostics and Screening of the Colon Cancer, Praktich. Onkol., 2002, no. 10, pp. 77–81.

  12. Rak obodochnoi i pryamoi kishki (Colon and Rectum Cancer), Knysh, V.I., Ed., Moscow: Meditsina, 1997.

    Google Scholar 

  13. Rak tolstoi kishki (The Colon Cancer), Meierkhardt, Dzh. and Sanderz, M., Eds., Moscow: Rid Elsevier, 2009.

    Google Scholar 

  14. Rak u pozhilykh (Cancer in Elderly People), Anisimov, V.N., Moiseenko, V.M., Khanson, K.P., Eds., St. Petersburg: N-L, 2004.

    Google Scholar 

  15. Fedorov, V.D., Therapy of the Colon Polyps, Khirurgiya, 1987, no. 1, pp. 82–86.

  16. AJCC Cancer Staging Handbook 7th ed., Springer Science+Business Media, 2010, 718 p.

  17. Andreyev, H.J., Norman, A.R., and Cunningham, D., Kirsten ras Mutations in Patients with Colorectal Cancer: The Multicenter “RASCAL” Study, J. Natl. Cancer Inst., 1998, vol. 90, no. 9, pp. 675–684.

    Article  PubMed  CAS  Google Scholar 

  18. Bos, J.L., Ras Oncogenes in Human Cancer: A Review, Cancer Res., 1989, vol. 49, pp. 4682–4689.

    PubMed  CAS  Google Scholar 

  19. Brink, M., De Goeij, A.F.P.M., Weijenberg, M.P., et al., K-ras Oncogene Mutations in Sporadic Colorectal Cancer in the Netherlands Cohort Study, Carcinogenesis, 2003, vol. 24, no. 4, pp. 703–710.

    Article  PubMed  CAS  Google Scholar 

  20. Brison, O., Gene Amplification and Tumor Progression, Biochim. Biophys. Acta, 1993, vol. 1155, no. 1, pp. 25–41.

    PubMed  CAS  Google Scholar 

  21. Cancer Incidence in Five Continents, Curado, M.P., et al., Eds., IARC, 2007, vol. 9, 896 p.

  22. Diamandis, E.P., Oncogenes and Tumor Suppressor Genes: New Biochemical Tests, Critical Rev. Clin. Lab. Sci., 1992, vol. 29, nos. 3–4, pp. 269–305.

    Article  CAS  Google Scholar 

  23. Di Fiore, F., Blanchard, F., Charbonnier, F., et al., Clinical Relevance of K-RAS Mutation Detection in Metastatic Colorectal Cancer Treated by Cetuximab Plus Chemotherapy, Brit. J. Cancer, 2007, vol. 96, pp. 1166–1169.

    Article  PubMed  Google Scholar 

  24. DNA Sequencing II: Optimizing Preparation and Cleanup, Kieleczawa, J., Ed., Sudbury MA: Jones and Bartlett Publishers, 2006, pp. 85–98.

    Google Scholar 

  25. Fearon, E.R. and Vogelstein, B., A Genetic Model for Colorectal Tumorigenesis, Cell, 1990, vol. 61, pp. 759–767.

    Article  PubMed  CAS  Google Scholar 

  26. Finkelstein, S.D., Sayegh, R., Christensen, S., and Swalsky, P.A., Genotypic Classification of Colorectal Adenocarcinoma. Biologic Behavior Correlates with K-ras-2 Mutation Type, Cancer, 1993, vol. 71, pp. 3827–3838.

    Article  PubMed  CAS  Google Scholar 

  27. Jass, J.R., Colorectal Adenoma Progression and Genetic Change: Is There a Link?, Ann. Med., 1995, vol. 27, pp. 301–306.

    Article  PubMed  CAS  Google Scholar 

  28. Krtolica, K., Krajnovic, M., Usaj-Knezevic, S., et al., Comethylation of P 16 and MGMT Genes in Colorectal Carcinoma: Correlation with Clinicopathological Features and Prognostic Value, World J. Gastroenterol., 2007, vol. 13, no. 8, pp. 1187–1194.

    PubMed  CAS  Google Scholar 

  29. Lièvre, A., Bachet, J.B., Boige, V., et al., K-RAS Mutations as an Independent Prognostic Factor in Patients with Advanced Colorectal Cancer Treated with Cetuximab, J. Clin. Oncol., 2008, vol. 26, no. 3, pp. 374–379.

    Article  PubMed  Google Scholar 

  30. Richman, S.D., Seymour, M.T., Chambers, P., et al., K-RAS and BRAF Mutations in Advanced Colorectal Cancer Are Associated with Poor Prognosis but Do not Preclude Benefit from Oxaliplatin or Irinotecan: Results from the MRC FOCUS Trial, J. Clin. Oncol., 2009, vol. 27, no. 35, pp. 5931–5937.

    Article  PubMed  CAS  Google Scholar 

  31. Schimanski, C.C., Zimmermann, T., Schmidtmann, I., et al., K-Ras Mutation Status Correlates with the Expression of VEGFR1, VEGFR2, and PDGFRalpha in Colorectal Cancer, Int. J. Colorectal. Dis., 2010, vol. 25, no. 2, pp. 181–186.

    Article  PubMed  Google Scholar 

  32. Siena, S., Sartore-Bianchi, A., Di Nicolantonio, F., et al., Biomarkers Predicting Clinical Outcome of Epidermal Growth Factor Receptor-Targeted Therapy in Metastatic Colorectal Cancer, J. Natl. Cancer Inst., 2009, vol. 101, no. 19, pp. 1308–1324.

    Article  PubMed  CAS  Google Scholar 

  33. Smith, G., Bounds, R., Wolf, H., et al., Activating K-Ras Mutations Outwith “Hotspot” Codons in Sporadic Colorectal Tumors-Implications for Personalized Cancer Medicine, Brit. J. Cancer, 2010, vol. 102, no. 4, pp. 693–703.

    Article  PubMed  CAS  Google Scholar 

  34. Soliman, A.S., Bondy, M.L., El-Badawy, S.A., et al., Contrasting Molecular Pathology of Colorectal Carcinoma in Egyptian and Western Patients, Brit. J. Cancer, 2001, vol. 85, no. 7, pp. 1037–1046.

    Article  PubMed  CAS  Google Scholar 

  35. Vogelstein, B., Fearon, E.R., Hamilton, S.R., et al., Genetic Alterations during Colorectal-Tumor Development, N. Engl. J. Med., 1988, vol. 319, no. 9, pp. 525–532.

    Article  PubMed  CAS  Google Scholar 

  36. Yunxia, Z., Jun, C., Guanshan, Zh., et al., Mutations in Epidermal Growth Factor Receptor and K-ras in Chinese Patients with Colorectal Cancer, BMC Med. Genet., 2010, vol. 11, no. 34, pp. 1–10.

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Petrov Research Institute of Oncology, Pesochnyi-2, Leningradskaya ul. 68, St. Petersburg, 197758, Russia

    A. V. Belyaeva, G. A. Yanus, E. N. Suspitsyn, O. A. Zaitseva, O. S. Yatsuk, A. B. Moiseenko, A. V. Gulyaev & E. N. Imyanitov

  2. St. Petersburg State Pediatric Academy, Litovskaya ul. 2, St. Petersburg, 194100, Russia

    G. A. Yanus, E. N. Suspitsyn & E. N. Imyanitov

  3. Mechnikov Northwest State Medical University, Kirochnaya ul. 41, St. Petersburg, 191015, Russia

    E. N. Imyanitov

Authors
  1. A. V. Belyaeva
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. G. A. Yanus
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. E. N. Suspitsyn
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. O. A. Zaitseva
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. O. S. Yatsuk
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. A. B. Moiseenko
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. A. V. Gulyaev
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. E. N. Imyanitov
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to A. V. Belyaeva.

Additional information

Original Russian Text © A.V. Belyaeva, G.A. Yanus, E.N. Suspitsyn, O.A. Zaitseva, O.S. Yatsuk, A.B. Moiseenko, A.V. Gulyaev, E.N. Imyanitov, 2012, published in Uspekhi Gerontologii, 2012, Vol. 25, No. 1, pp. 72–78.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Belyaeva, A.V., Yanus, G.A., Suspitsyn, E.N. et al. Age-related and clinicopathological features of colorectal cancer associated with K-ras gene status. Adv Gerontol 2, 306–311 (2012). https://doi.org/10.1134/S2079057012040030

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1134/S2079057012040030

Keywords

Search

Navigation