Abstract
This review describes the interplay between the thymus and pineal gland during their involution connected with aging. The data of a few studies on the effects of thymus peptides on the pineal gland and pineal peptides on the thymus are consolidated. Analysis of these data demonstrates that pineal peptides (epithalamin and epithalon) have a more pronounced geroprotective effect on the thymus as compared with those of the thymus peptides (thymalin and thymogen) on the pineal gland. The key processes involved in the restoration of the thymus function in its age-related involution by epithalamin and epithalon are the immunoendocrine mechanisms implemented at the level of transcription activation of various proteins.
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References
Anisimov, V.N., Khavinson, V.Kh., and Morozov, V.G., Role of Epiphyseal Peptides in regulation of Homeostasis: Twenty Years of Research Experience, Usp. Sovrem. Biol., 1993, vol. 113, no. 6, pp. 752–762.
Kvetnaya, T.V., Knyaz’kin, I.V., and Kvetnoi, I.M., Melatonin - neiroimmunoendokrinnyi marker vozrastnoi patologii (Melatonin as Neuroimmunoendocrine Marker of Age-Related Pathologies), St. Petersburg: Dean, 2005.
Kvetnoi, I.M., Yarilin, A.A., Polyakova, V.O., and Knyaz’kin, I.V., Neiroimmunoendokrinologiya timusa (Neuroimmunoendocrinology of Thymus), St. Petersburg: Dean, 2005.
Knyaz’kin, I.V., Pineal Gland and Extrapineal Sources of Melatonin in Visceral Organs at Natural Senescence of a Man, Uspekhi Gerontol., 2008, vol. 21, no. 1, pp. 83–85.
Korkushko, O.V., Lapin, B.A., Goncharova, N.D., et al., Stabilizing Effect of Epiphyseal Peptides on Diurnal Rhythm of Melatonin in Old Monkeys and People, Uspekhi Gerontol., 2007, vol. 20, no. 1, pp. 74–85.
Labunets, I.F., Effect of Melatonin on Biorhythms of Functional Status of Thymus, Immune System and Adrenal Cortex in Old People, Problemy Stareniya i Dolgoletiya, 2005, vol. 14, no. 4, pp. 313–322.
Labunets, I.F., Effect of Biologically Active Factors of Thymus on Melatonin Secreting Function of Epiphysis in Animals of Different Age: Possible Mechanisms, Uspekhi Gerontol., 2007, vol. 20, no. 1, pp. 86–91.
Morozov, V.G. and Khavinson, V.Kh., Extraction Lymphocytes and Thymus Polypeptides Coordinating Intercellular Cooperation in the System Immunity from the Bone Marrow, Dokl. Akad. Nauk SSSR, 1981, vol. 261, no. 1, pp. 235–239.
Pal’tsev, M.A. and Kvetnoi, I.M., Rukovodstvo po neiroimmunoendokrinologii (Manual on Neuroimmunoendocrinology), Moscow: Meditsina, 2006.
Pirozhkov, S.I. and Safarova, G.L., Tendencies of Senescence of Russian and Ukrainian People: Demographic Aspects, Uspekhi Gerontol., 2000, no. 7, pp. 14–21.
Polyakova, V.O. and Kvetnoi, I.M., Structural-Functional Resemblance of Pineal Gland and Thymus: Role and Significance in Neuroimmunoendocrine Regulation of Homeostasis, Neiroimmunologiya, 2009, vol. 7, no. 1, pp. 85–86.
Safarova, G.L., Demography of Senescence: Contemporary Status and Study Priorities, Uspekhi Gerontol., 2009, vol. 22, no. 1, pp. 49–59.
Khavinson, V.Kh., Peptidnaya regulyatsiya stareniya (Peptide Regulation of Senescence), St. Petersburg: Nauka, 2009.
Khavinson, V.Kh. and Anisimov, V.N., Peptidnye bioregulyatory i starenie (Peptide Bioregulators and Senescence), St. Petersburg: Nauka, 2003.
Khavinson, V.Kh. and Anisimov, V.N., Thirty Five Years of Research Experience of Peptide Regulation of Senescence, Uspekhi Gerontol., 2009, vol. 7, no. 1, pp. 11–23.
Khavinson, V.Kh. and Malinin, V.V., Mechanisms of Geroprotective Action of Peptides, Byul. Eksper. Biol., 2002, vol. 133, no. 1, pp. 4–10.
Khavinson, V.Kh. and Morozov, V.G., Peptidy epifiza i timusa v regulyatsii stareniya (Epiphyseal and Thymic Peptides in Regulation of Senescence), St. Petersburg: Foliant, 2001.
Khavinson, V.Kh., Kvetnoi, I.M., Yuzhakov, V.V., et al., Peptidergicheskaya regulyatsiya gomeostaza (Peptide Regulation of Homeostasis), St. Petersburg: Nauka, 2003.
Anisimov V.N., Khavinson V.Kh. Pineal peptides as modulators of ading. In: Aging interrentions and therapies, Rottan S.I.S., Ed., World Scientific, 2005, pp. 127–146.
El-Sokkary, G.H., Reiter, R.J., and Abdel-Ghaffar, S.K., Melatonin Supplementation Restores Cellular Proliferation and DNA Synthesis in the Splenic and Thymic Lymphocytes of Old Rats, Neuroendocr. Lett., 2003, vol. 24, nos. 3–4, pp. 215–223.
Fabris, N., Vocchegiani, E., and Provinciali, M., Plasticity of Neuroendocrine-Thymus Interaction During Aging, Exp. Geront., 1997, vol. 32, nos. 4–5, pp. 415–429.
Guerrero, J.M. and Reiter, R.J., Melatonin-Immune System Relationships, Curr. Topics Med. Chem., 2002, vol. 2, no. 2, pp. 167–179.
Khavinson, V.Kh., Peptides and Aging, Neuroendocrinol. Lett. (Special Issue), 2002.
Khavinson, V.Kh. and Malinin, V.V., Gerontological Aspects of Genome Peptide Regulation, Basel: (Switzerland): Karger AG, 2005.
Khavinson, V. and Morozov, V., Peptides of Pineal Gland and Thymus Prolong Human Life, Neuroendocrinol. Lett., 2003, vol. 24, nos. 3–4, pp. 233–240.
Tian, Y.M., Li, P.P., and Jiang, X.F., Rejuvenation of Degenerative Thymus by Oral Melatonin Administration and the Antagonistic Action of Melatonin Against Hydroxyl Radical-Induced Apoptosis of Cultured Thymicytes in Mice, J. Pineal Res., 2001, vol. 31, no. 3, pp. 214–221.
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Original Russian Text © N.S. Lin’kova, V.O. Polyakova, I.M. Kvetnoi, A.V. Trofimov, N.N. Sevost’yanova, 2011, published in Uspekhi Gerontologii, 2011, Vol. 24, No. 1, pp. 38–42.
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Lin’kova, N.S., Polyakova, V.O., Kvetnoi, I.M. et al. Specific features in the pineal gland-thymus relationships during aging. Adv Gerontol 1, 295–298 (2011). https://doi.org/10.1134/S2079057011040096
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DOI: https://doi.org/10.1134/S2079057011040096