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Apoptosis-reactivating agents for targeted anticancer therapy

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Abstract

The review considers the current knowledge on molecular mechanisms of apoptosis. Particular emphasis is given to the key elements of the extrinsic death receptor pathway and the intrinsic mitochondrial pathway. Dysregulation of apoptotic pathways is considered as a key factor in the survival of cancer cells in response to conventional chemotherapeutic drugs or radiation therapy. Substances that selectively reactivate apoptosis in malignant cells are considered as the promising candidate anticancer drugs, which have now entered various phases of clinical trials. The modern techniques allowing non-invasive visualization of apoptotic cells with special reference to therapy-induced cell death are briefly surveyed.

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  1. Kavetsky Institute of Experimental Pathology, Oncology, and Radiobiology, National Academy of Sciences of Ukraine, 45 Vasilkivska Str., Kyiv, 03022, Ukraine

    A. A. Philchenkov

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Original Russian Text © A.A. Philchenkov, 2012, published in Biomeditsinskaya Khimiya.

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Philchenkov, A.A. Apoptosis-reactivating agents for targeted anticancer therapy. Biochem. Moscow Suppl. Ser. B 6, 343–358 (2012). https://doi.org/10.1134/S1990750812030043

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