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Analysis of ERK1/2 kinases in the inferior colliculus of rats genetically prone to audiogenic seizures during postnatal development

  • Biochemistry, Biophysics, and Molecular Biology
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Abstract

The activity of ERK1/2 kinases in the quadrigemina inferior colliculus of Krushinsky–Molodkina rats of different age, which are characterized by an increased seizure readiness compared to Wistar rats, was analyzed. An increased (probably genetically determined) activity of these enzymes during the development of epileptiform activity in ontogeny was found, which may be the cause of abnormalities in the neurotransmitter system functioning.

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Authors and Affiliations

  1. Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences, St. Petersburg, 194223, Russia

    E. V. Chernigovskaya, O. O. Lebedenko, A. V. Nidenfyur, L. S. Nikitina & M. V. Glazova

Authors
  1. E. V. Chernigovskaya
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  2. O. O. Lebedenko
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  3. A. V. Nidenfyur
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  4. L. S. Nikitina
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  5. M. V. Glazova
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Correspondence to E. V. Chernigovskaya.

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Original Russian Text © E.V. Chernigovskaya, O.O. Lebedenko, A.V. Nidenfyur, L.S. Nikitina, M.V. Glazova, 2017, published in Doklady Akademii Nauk, 2017, Vol. 476, No. 1, pp. 113–116.

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Chernigovskaya, E.V., Lebedenko, O.O., Nidenfyur, A.V. et al. Analysis of ERK1/2 kinases in the inferior colliculus of rats genetically prone to audiogenic seizures during postnatal development. Dokl Biochem Biophys 476, 296–298 (2017). https://doi.org/10.1134/S1607672917050015

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  • DOI: https://doi.org/10.1134/S1607672917050015

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