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Synthesis and properties of derivatives of pyrimidin-5-ylpropanoic acids and 8-aryl-4-methyl- and 4,6-dimethyl-2-phenyl-5,6,7,8-tetrahydropyrido-[2,3-d]pyrimidin-7-ones

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Abstract

Proceeding from 3-(4-methyl-6-oxo-2-phenyl-1,6-dihydro-5-pyrimidinyl)propanoic and 2-methylpropanoic acids by successive reactions of chlorination, amination, and heterocyclization 4-amino-substituted pyrimidines were synthesized: 5,6,7,8-tetrahydropyrido[2,3-d]pyrimidine derivatives and 4-methyl-2-phenyl-5,6-dihydrobenzo[4′,5′]imidazo[2′,1′:6,1]pyrido[2,3-d]pyrimidine which we had previously obtained by alternative method. Antibacterial properties of the synthesized compounds were studied.

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Authors and Affiliations

  1. Scientific and Technologic Center of Organic and Pharmaceutical Chemistry, National Academy of Sciences of Armenia, Mnjoyan Institute of Fine Organic Chemistry, pr. Azatutyan 26, Yerevan, 0014, Armenia

    A. A. Harutyunyan, R. V. Paronikyan & H. M. Stepanyan

  2. Center of Study of Molecular Structure, National Academy of Sciences of Armenia, Yerevan, Armenia

    G. A. Panosyan & S. G. Chishmarityan

Authors
  1. A. A. Harutyunyan
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  2. G. A. Panosyan
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  3. S. G. Chishmarityan
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  4. R. V. Paronikyan
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  5. H. M. Stepanyan
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Corresponding author

Correspondence to A. A. Harutyunyan.

Additional information

Original Russian Text © A.A. Harutyunyan, G.A. Panosyan, S.G. Chishmarityan, R.V. Paronikyan, H.M. Stepanyan, 2015, published in Zhurnal Organicheskoi Khimii, 2015, Vol. 51, No. 5, pp. 722–726.

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Harutyunyan, A.A., Panosyan, G.A., Chishmarityan, S.G. et al. Synthesis and properties of derivatives of pyrimidin-5-ylpropanoic acids and 8-aryl-4-methyl- and 4,6-dimethyl-2-phenyl-5,6,7,8-tetrahydropyrido-[2,3-d]pyrimidin-7-ones. Russ J Org Chem 51, 705–710 (2015). https://doi.org/10.1134/S1070428015050218

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  • DOI: https://doi.org/10.1134/S1070428015050218

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