, Volume 42, Issue 3, pp 365-368

Synthesis of chiral 5-aryltetrahydrofuran-2-ones via yeast bioreduction of γ-keto acids and their esters

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Abstract

Enantioselective reduction of γ-keto acids and related γ-keto esters with Saccharomyces cerevisiae (baker’s yeast) leads to the formation of the corresponding chiral 5-aryltetrahydrofuran-2-ones in satisfactory chemical and optical yields.