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Low-basic anion exchangers based on glycidyl methacrylate for selective sorption of endotoxin

  • Sorption and Ion Exchange Processes
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Abstract

Radical copolymerization of glycidyl methacrylate with vinylpyrrolidone and glycidyl methacrylate with vinylformamide, followed by modification with glucosamine, was used to synthesize low-basic anion exchangers for extracorporeal removal of endotoxins from blood plasma. The effect of the glucosamine concentration on the basicity of the polymeric sorbents was studied and optimal conditions for modification of network polymers were found. Their physicochemical and sorption properties were examined. It was shown that the main contribution to the change in the free energy of sorption of the endotoxin by the synthesized polymeric sorbents is made by hydrophobic interactions, with the increase in the basicity of the anion exchangers leading to a rise in sorption capacities.

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Authors and Affiliations

  1. Institute of Macromolecular Compounds, Russian Academy of Sciences, Bol’shoi pr. 31, St. Petersburg, 199004, Russia

    I. V. Polyakova, N. A. Sverlova, A. R. Groshikova, O. A. Pisarev & E. F. Panarin

  2. Department of Medical Physics, Peter the Great St. Petersburg Polytechnic University, ul. Politekhnicheskaya 29, St. Petersburg, 195251, Russia

    O. A. Pisarev & E. F. Panarin

Authors
  1. I. V. Polyakova
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  2. N. A. Sverlova
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  3. A. R. Groshikova
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  4. O. A. Pisarev
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  5. E. F. Panarin
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Corresponding author

Correspondence to I. V. Polyakova.

Additional information

Original Russian Text © I.V. Polyakova, N.A. Sverlova, A.R. Groshikova, O.A. Pisarev, E.F. Panarin, 2015, published in Zhurnal Prikladnoi Khimii, 2015, Vol. 88, No. 2, pp. 256–263.

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Polyakova, I.V., Sverlova, N.A., Groshikova, A.R. et al. Low-basic anion exchangers based on glycidyl methacrylate for selective sorption of endotoxin. Russ J Appl Chem 88, 259–266 (2015). https://doi.org/10.1134/S1070427215020111

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  • DOI: https://doi.org/10.1134/S1070427215020111

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