Abstract
Study results on the condition of endogenous ethanol—acetaldehyde system in northern red-backed vole (Myodes (=Clethrionomys) rutilus Pallas, 1779), common species of northern latitudes, are presented. Concentrations of endogenous ethanol (EE) and acetaldehyde (EA) in blood, activities of alcohol dehydrogenase in ethanol oxidation reactions (ADHI) and liver acetaldehyde (ADHII) and aldehyde dehydrogenase (ALDH) reduction, and catalytic parameters of these enzymes are determined for winter and summer periods. Changes in ethanol—metabolizing dehydrogenase enzyme system in northern red-backed vole leading to statistically significant (p < 0.01) increase in blood EE and EA concentrations compared to white nonpedigreed laboratory rats without adaptations to cold (especially in winter period) are determined to serve ecoadaptive, antistress functions, comprising one of the systems for regulation of metabolism intensity in small mammals inhabiting extreme northern conditions. Ecological—physiological functions of EE and EA system are increasing the organism’s resistance to the influence of cold temperatures and maintaining thermoregulation even under rapid, considerable environmental temperature drops.
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References
Agarwal, D.P. and Seitz, H.K., Alcohol in Health and Disease, New York: Marcel Dekker, 2001.
Anufriev, A.I., Ekologicheskie mekhanizmy temperaturnykh adaptatsii mlekopitayushchikh i zimuyushchikh ptits Yakutii (Ecological Mechanisms of Temperature Adaptations i Mammals and Wintering Birds of Yakutia), Novosibirsk: Sib. Otd., Ross. Akad. Nauk, 2013.
Biokhimiya (Biochemistry), Komov, V.P. and Shvedov, V.N., Eds., Moscow: Drofa, 2004, pp. 68–94.
Bol’shakov, V.N., Koval’chuk, L.A., and Yastrebov, A.P., Energeticheskii obmen u polevok i ero izmeneniya v ekstremal’nykh usloviyakh (Energy Metabolism of Voles and Its Changes under Extreme Conditions), Sverdlovsk: Ural. Nauch. Tsentr, Akad. Nauk SSSR, 1984.
Burov, Yu.V., Treskov, V.G., Kampov-Polevoi, A.B., et al., Endogenous ethanol level and alcohol motivation, Bull. Exp. Biol. Med., 1983, vol. 96, no. 5, pp. 1572–1573.
Chernobrovkina, T.V. and Kershengolts, B.M., Fundamental’nye i mediko-sotsial’nye aspekty addiktologii (Fundamental and Social Aspects of Addictology), Yakutsk: Sfera, 2011, vol. 1.
Glants, S.A., Primer of Biostatistics, New York: McGraw-Hill, 1996, 4th ed.
Ivanter, E.V., Ivanter, T.V., and Tumanov, I.L., Adaptivnye osobennosti melkikh mlekopitayushchikh (Specific Adaptive Features of Small Mammals), Leningrad: Nauka, 1985.
Jones, A., Mardh, G., and Anggard, E., Determination of endogenous ethanol in blood and breath by gas chromatography–mass spectrometry, Pharmacol. Biochem. Behav., 1983, vol. 18, no. 1, pp. 267–272.
Jornvall, H., Hoog, J., Bahr-Lindstrom, H., et al., Alcohol dehydrogenases and aldehyde dehydrogenases, Biochem. Soc. Trans., 1988, vol. 6, no. 3, pp. 223–227.
Kalabukhov, N.I., Spyachka mlekopitayushchikh (Hibernation in Mammals), Moscow: Nauka, 1985.
Karaseva, E.V. and Telitsyna, A.Yu., Metody izucheniya gryzunov v polevykh issledovaniyakh (Methods of Field Studies on Rodents), Moscow: Nauka, 1995.
Kershengolts, B.M. and Serkina, E.V., Nekotorye metodicheskie podkhody k izucheniyu metabolizma etanola (Some Methodological Approaches to the Study of Ethanol Metabolism), Available from VINITI, 1981, no. D-3793.
Kershengolts, B.M. and Turnin, Kh.Kh., Alcohol dehydrogenase and aldehyde dehydrogenase polymorphism in population groups of Yakutia and prediction of population resistance to alcoholism, Uch. Zap. Yakutsk. Dos. Univ., Ser. Biol., 1994, pp. 138–149.
Khaskin, V.V., Energetika teploobrazovaniya i adaptatsii k kholodu (Energetics of Heat Production and Cold Adaptation), Novosibirsk: Nauka, 1975.
Khlenyy, E.S., Kolosova, O.N., and Kerschengolts, B.M., Role of endogenous system ethanol–acetaldehyde in metabolism regulation in organisms of hibernating animals, Cryobiology, 2010, vol. 61, no. 3, pp. 397–398.
Kolosova, O.N. and Kershengolts, B.M., Stabilization of homeostasis in rats during cold exposure with ethanol, Bull. Exp. Biol. Med., 2016, vol. 160, no. 3, pp. 300–303.
Kolosova, O.N., Kershengolts, B.M., and Solomonov, N.G., Endogenous ethanol and acetaldehyde in the mechanisms regulating vital activities during hibernation, Dokl. Biol. Sci., 2011, vol. 441, pp. 347–349.
Koval’chuk L.A. Specific features of energy metabolism and blood system in small mammals under extreme influences, Extended Abstract of Doctoral (Biol.) Dissertation, Syktyvkar, 1995.
Mlekopitayushchie Yakutii (Mammals of Yakutia), Novosibirsk: Nauka, 1971.
Olenev, G.V. and Grigorkina, E.B., Functional patterns of life activities of rodent populations in the winter season, Russ. J. Ecol., 2014, vol. 45, no. 6, pp. 480–489.
Ozernyuk, N.D., Temperature limits of life, Priroda (Moscow), 2003, no. 2, pp. 56–61.
Safronov, V.M., Adaptive features of thermoregulation and energy balance maintenance in murine rodents, Vestn. Tomsk. Gos. Univ., Ser. Biol., 2009, no. 4 (8), pp. 47–61.
Shadrina, E.G. and Vol’pert, Ya.L., The ecology of the root vole in the Indigirka River valley, Nauka Obraz., 2013, no. 2 (70), pp. 94–100.
Shoubridge, E.A. and Hochachka, P.W., Ethanol: Novel end product of vertebrate anaerobic metabolism, Science, 1980, vol. 209, no. 4453, pp. 308–309.
Slonim, A.D., The theory of physiological adaptations, in Rukovodstvo po fiziologii: ekologicheskaya fiziologiya zhivotnykh (A Manual of Physiology: Ecological Physiology of Animals), Leningrad: Nauka, 1979, part 1, p. 79–182.
Slonim, A.D., Thermal adaptations and compensations in homeotherms, in Fiziologiya zhivotnykh (Animal Physiology), Leningrad: Nauka, 1981, part 3, pp. 41–47.
Tulikova, N.V., Studies on reproduction and age composition of small mammal populations, in Metody izucheniya prirodnykh ochagov boleznei cheloveka (Methods of Studies on Natural Foci of Human Diseases), Moscow, 1964, pp. 154–191.
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Original Russian Text © O.N. Kolosova, B.M. Kershengol’ts, 2017, published in Ekologiya, 2017, No. 1, pp. 54–59.
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Kolosova, O.N., Kershengol’ts, B.M. Endogenous ethanol and acetaldehyde in the mechanisms of adaptation of small mammals to northern conditions. Russ J Ecol 48, 68–72 (2017). https://doi.org/10.1134/S1067413617010088
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DOI: https://doi.org/10.1134/S1067413617010088