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In vitro lipid-lowering and fibrinolytic effects of regulatory leucine-containing glyprolines in human blood

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Abstract

The lipid-lowering, fibrinolytic, and anticoagulant effects of leucine-containing glyprolines, Pro-Gly-Pro-Leu and Leu-Pro-Gly-Pro, were studied in vitro in the blood of patients with disorders of lipid metabolism. The lipid-lowering impact of glyprolines and their ability to reduce the polymerization and to increase the depolymerization of fibrin in human blood were found. Possible mechanisms of lipolytic action of peptides by means of modulation of the lipid-dependent phospholipase A2 were proposed.

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Authors and Affiliations

  1. Scientific Center of Neurology, Russian Academy of Medical Sciences, Volokolamskoe sh. 80, Moscow, 125367, Russia

    A. A. Shabalina, M. V. Kostyreva, M. M. Tanashyan & Z. A. Suslina

  2. Department of Biology, Moscow State University, Moscow, 119991, Russia

    L. A. Lyapina & D. L. Rochev

Authors
  1. A. A. Shabalina
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  2. L. A. Lyapina
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  3. D. L. Rochev
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  4. M. V. Kostyreva
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  5. M. M. Tanashyan
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  6. Z. A. Suslina
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Corresponding author

Correspondence to L. A. Lyapina.

Additional information

Original Russian Text © A.A. Shabalina, L.A. Lyapina, D.L. Rochev, M.V. Kostyreva, M.M. Tanashyan, Z.A. Suslina, 2015, published in Izvestiya Akademii Nauk, Seriya Biologicheskaya, 2015, No. 1, pp. 85–89.

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Shabalina, A.A., Lyapina, L.A., Rochev, D.L. et al. In vitro lipid-lowering and fibrinolytic effects of regulatory leucine-containing glyprolines in human blood. Biol Bull Russ Acad Sci 42, 74–77 (2015). https://doi.org/10.1134/S1062359015010112

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  • DOI: https://doi.org/10.1134/S1062359015010112

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