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Spectrophotometric determination of purine alkaloids by flow injection and sequential injection analysis

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Abstract

Procedures are developed for the flow-injection and sequential-injection determination of purine (xanthine) alkaloids (caffeine, theophylline, theobromine, and aminophylline) based on their spectrophoto-metric detection by the oxidative coupling reaction with 3-methyl-2-benzothiazolinone hydrazone hydrochloride under the action of potassium periodate in a weakly acidic aqueous medium (pH 5–6). The analytical range is 3–500 μg/mL, and throughput is 120–180 h–1. It is demonstrated that the developed procedures can be used for the quality control of pharmaceutical preparations.

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Authors and Affiliations

  1. Kurnakov Institute of General and Inorganic Chemistry, Russian Academy of Sciences, Leninskii pr. 31, Moscow, 119991, Russia

    L. K. Shpigun, E. Yu. Andryukhina & Ya. V. Shushenachev

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  1. L. K. Shpigun
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  2. E. Yu. Andryukhina
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  3. Ya. V. Shushenachev
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Correspondence to L. K. Shpigun.

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Original Russian Text © L.K. Shpigun, E.Yu. Andryukhina, Ya.V. Shushenachev, 2015, published in Zhurnal Analiticheskoi Khimii, 2015, Vol. 70, No. 8, pp. 811–820.

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Shpigun, L.K., Andryukhina, E.Y. & Shushenachev, Y.V. Spectrophotometric determination of purine alkaloids by flow injection and sequential injection analysis. J Anal Chem 70, 926–935 (2015). https://doi.org/10.1134/S1061934815080158

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  • DOI: https://doi.org/10.1134/S1061934815080158

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