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A highly sensitive spectrophotometric determination of sodium 2-sulfanylethanesulfonate in pharmaceutical preparations

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Abstract

The aim of this research was to develop a new sensitive and simple spectrophotometric method for the determination of sodium 2-sulfanylethanesulfonate (SSES) with leucocrystal violet. The procedure is based on a redox reaction occurring between the SSES and potassium iodate in an acidic medium. Formed in stoichiometric quantity iodine oxidizes leucocrystal violet to the crystal violet dye, whose coloring is a base of the spectrophotometric measurements. The crystal violet dye formed shows maximum and stable absorbance at pH = 4.1 ± 0.1 and λ = 590 nm. The molar absorptivity, limit of detection and limit of determination of the method were calculated to be 6.98 × 104 L/mol cm, 0.10 and 0.13 μg/mL, respectively. The color system obeys Beer’s law in the range 0.2–2.0 μg/mL of SSES. The optimum analytical conditions were evaluated. The proposed method has been successfully applied to the determination of SSES in pharmaceutical preparations, without the need of any complicated instrumentation. Reliability of determination was confirmed applying standard iodometric method, recommended by European and Polish Pharmacopoeia.

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Authors and Affiliations

  1. Institute of Chemistry, University of Silesia, 9 Szkolna Street, 40-006, Katowice, Poland

    Barbara Szpikowska-Sroka & Aleksandra Guz

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  1. Barbara Szpikowska-Sroka
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  2. Aleksandra Guz
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Correspondence to Barbara Szpikowska-Sroka.

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Szpikowska-Sroka, B., Guz, A. A highly sensitive spectrophotometric determination of sodium 2-sulfanylethanesulfonate in pharmaceutical preparations. J Anal Chem 70, 831–836 (2015). https://doi.org/10.1134/S1061934815070163

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  • DOI: https://doi.org/10.1134/S1061934815070163

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