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Amphiphilic derivatives of dextran and related nanoparticles

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Abstract

Graft block copolymers of poly(ɛ-caprolactone) containing various amounts of dextran [dextranpoly(ɛ-caprolactone) copolymers] have been prepared and characterized. The methods of obtaining nanoparticles based on the dextran-poly(ɛ-caprolactone) graft block copolymers have been elaborated and optimized. It has been demonstrated that the electrokinetic potential of nanoparticles may be varied relative to the composition of the polymer, the structure of nanoparticles, and the ionic strength of solution. Under physiological conditions, the nanoparticles behave as stable colloids. On the basis of the experimental evidence, conclusions concerning the structure of the nanoparticles have been made.

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Authors and Affiliations

  1. Faculty of Chemistry, Moscow State University, Leninskie gory, Moscow, 119992, Russia

    A. L. Villemson & N. I. Larionova

  2. Faculté de Pharmacie, UMR CNRS 8612, Université Paris Sud XI, 92296, Châtenay Malabry, France

    P. Couvreur & R. Gref

Authors
  1. A. L. Villemson
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  2. P. Couvreur
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  3. R. Gref
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  4. N. I. Larionova
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Additional information

Original Russian Text © A.L. Villemson, P. Couvreur, R. Gref, N.I. Larionova, 2007, published in Vysokomolekulyarnye Soedineniya, Ser. A, 2007, Vol. 49, No. 6, pp. 1056–1064.

This work was supported by the Federal Agency of Science (state contract 05.512.11.2017) and the Russian Foundation for Basic Research (project no. 05-04-48747).

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Villemson, A.L., Couvreur, P., Gref, R. et al. Amphiphilic derivatives of dextran and related nanoparticles. Polym. Sci. Ser. A 49, 708–715 (2007). https://doi.org/10.1134/S0965545X07060120

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  • DOI: https://doi.org/10.1134/S0965545X07060120

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