Abstract
The FTIR spectra of the solutions of biologically active molecules (screened phenylazomethines) in CCl4 are studied. The role of the OH- and N=C groups in the formation of the intramolecular H bonds is analyzed. The analysis of the FTIR spectra shows that three types of H bonds (O-H…O-H, O-H…N=C, and O-H…O-H…N=C) are possible in the molecules under study. A correlation of the H-bond formation in the phenylazomethine molecules and the antivirus properties of such molecules is revealed. The antivirus activity is observed for molecules that exhibit intramolecular O-H…O-H…N=C bonds in the absence of free hydroxyls. The antivirus activity decreases when the molecule contains additional OH groups that are not involved in H bonds.
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Original Russian Text © G.B. Tolstorozhev, M.V. Bel’kov, I.V. Skornyakov, O.I. Shadyro, G.A. Ksendzova, V.L. Sorokin, 2014, published in Optika i Spektroskopiya, 2014, Vol. 117, No. 1, pp. 47–52.
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Tolstorozhev, G.B., Bel’kov, M.V., Skornyakov, I.V. et al. Intramolecular hydrogen bonds in the phenylazomethine biomolecules. Opt. Spectrosc. 117, 44–48 (2014). https://doi.org/10.1134/S0030400X14070236
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DOI: https://doi.org/10.1134/S0030400X14070236