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Rabies vaccines: Current status and prospects for development

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Abstract

Rabies is an infectious disease among humans and animals that remains incurable, despite its longstanding research history. The only way to prevent the disease is prompt treatment, including vaccination as an obligatory component and administration of antirabies immunoglobulin as a supplement. Since the first antirabies vaccination performed in the 19th century, a large number of different rabies vaccines have been developed. Progress in molecular biology and biotechnology enabled the development of effective and safe technologies of vaccine production. Currently, new-generation vaccines are being developed based on recombinant rabies virus strains or on the production of an individual recombinant rabies antigen—glycoprotein (G protein), either as a component of nonpathogenic viruses, or in plants, or in the form of DNA vaccines. In this review, the main modern trends in the development of rabies vaccines have been discussed.

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Abbreviations

WHO:

World Health Organization

CRV:

culturebased rabies vaccine

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Authors and Affiliations

  1. Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, 119991, Russia

    E. S. Starodubova, O. V. Preobrazhenskaia, Y. V. Kuzmenko, A. A. Latanova & V. L. Karpov

  2. Skryabin Moscow State Academy of Veterinary Medicine and Biotechnology, Moscow, 109472, Russia

    E. I. Yarygina

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  1. E. S. Starodubova
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  2. O. V. Preobrazhenskaia
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  3. Y. V. Kuzmenko
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  4. A. A. Latanova
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  6. V. L. Karpov
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Correspondence to E. S. Starodubova.

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Original Russian Text © E.S. Starodubova, O.V. Preobrazhenskaia, Y.V. Kuzmenko, A.A. Latanova, E.I. Yarygina, V.L. Karpov, 2015, published in Molekulyarnaya Biologiya, 2015, Vol. 49, No. 4, pp. 577–584.

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Starodubova, E.S., Preobrazhenskaia, O.V., Kuzmenko, Y.V. et al. Rabies vaccines: Current status and prospects for development. Mol Biol 49, 513–519 (2015). https://doi.org/10.1134/S0026893315040172

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