Molecular Biology

, Volume 47, Issue 4, pp 476–487

Possibilities and effects of telomerase activation

  • N. A. Kovalenko
  • D. D. Zhdanov
  • T. F. Kovalenko

DOI: 10.1134/S0026893313040079

Cite this article as:
Kovalenko, N.A., Zhdanov, D.D. & Kovalenko, T.F. Mol Biol (2013) 47: 476. doi:10.1134/S0026893313040079


The mechanisms regulating the activity of telomerase, predominantly human telomerase, are considered in brief. The localization of telomerase complex components in the cell is described, and telomerase activities unrelated to telomere elongation are discussed. Human diseases that correlate with reduced telomerase activity, short telomeres, and rapid telomere shortening are overviewed. The possibilities to activate transcription of exogenous hTERT by various natural and synthetic compounds are described along with the effects of cell transfection with active hTERT. Exogenous hTERT activation increases the cell proliferation potential and may be employed in cell therapy. It is emphasized that elevated hTERT expression may cause cell malignant transformation, especially in the case of hTERT transfection. This possibility must be considered when choosing the means of telomerase activation for therapeutic purposes.


human telomerasetelomerase activatorshTERT gene



telomerase RNA


heat shock protein


short interfering RNA

Copyright information

© Pleiades Publishing, Ltd. 2013

Authors and Affiliations

  • N. A. Kovalenko
    • 1
  • D. D. Zhdanov
    • 2
  • T. F. Kovalenko
    • 3
  1. 1.RF Ministry of HealthSechenov First Moscow State Medical UniversityMoscowRussia
  2. 2.Orekhovich Institute of Biomedical ChemistryRussian Academy of Medical SciencesMoscowRussia
  3. 3.Shemyakin and Ovchinnikov Institute of Bioorganic ChemistryRussian Academy of SciencesMoscowRussia