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A biophysical model of the contractile activity of muscle cells

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Abstract

Muscle cells have a distinctive structure, a developed cytoskeleton, which occupies most of the cell’s volume and forms, among other things, the contractile apparatus. A mathematical model of the biomechanical behavior of the cell as a whole was suggested based on the equations of continuum mechanics, which was next modified to describe the contractile activity of a muscle cell as an elastic rod. The model considers the result of the transduction of external effects that are manifested as an internal deformation, which allows the evaluation of the mobility and/or the emerging tension in muscle cells under the effects of external factors.

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Authors and Affiliations

  1. Institute of Biomedical Problems, Russian Academy of Sciences, Khoroshevskoye sh. 76a, Moscow, 123007, Russia

    A. S. Pokusaev & I. V. Ogneva

  2. Sechenov First Moscow State Medical University, Ministry of Health of the Russian Federation, ul. Trubetskaya 8/2, Moscow, 119991, Russia

    I. V. Ogneva

  3. Konstantinov Petersburg Institute of Nuclear Physics, Kurchatov Institute National Research Center, Orlova Roshcha, Gatchina, Leningrad oblast, 188300, Russia

    I. V. Ogneva

Authors
  1. A. S. Pokusaev
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  2. I. V. Ogneva
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Correspondence to I. V. Ogneva.

Additional information

Original Russian Text © A.S. Pokusaev, I.V. Ogneva, 2015, published in Biofizika, 2015, Vol. 60, No. 6, pp. 1132–1137.

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Pokusaev, A.S., Ogneva, I.V. A biophysical model of the contractile activity of muscle cells. BIOPHYSICS 60, 940–945 (2015). https://doi.org/10.1134/S0006350915060202

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  • DOI: https://doi.org/10.1134/S0006350915060202

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