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Microtubular disrupter nocodazole and vesicular transport inhibitor brefeldin A attenuate the glutoxim effect on Na+ transport in frog skin

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Abstract

Using the voltage-clamp technique, a possible role of microtubules and vesicular transport in the effect of pharmacological analogue of oxidized glutathione, drug glutoxim, on Na+ transport in the frog Rana temporaria skin was investigated. It was shown for the first time that the disrupter of microtubules nocodazole or inhibitor of vesicular transport brefeldin A similarly modulate (completely inhibit) the stimulatory effect of glutoxim on Na+ transport. The data suggest the involvement of reorganization of microtubules and vesicular transport in the regulatory effect of glutoxim on Na+ transport.

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Correspondence to A. V. Melnitskaya.

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Original Russian Text © A.V. Melnitskaya, Z.I. Krutetskaya, S.N. Butov, N.I. Krutetskaya, V.G. Antonov, 2014, published in Biofizika, 2014, Vol. 59, No. 5, pp. 883–886.

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Melnitskaya, A.V., Krutetskaya, Z.I., Butov, S.N. et al. Microtubular disrupter nocodazole and vesicular transport inhibitor brefeldin A attenuate the glutoxim effect on Na+ transport in frog skin. BIOPHYSICS 59, 718–720 (2014). https://doi.org/10.1134/S0006350914050169

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  • DOI: https://doi.org/10.1134/S0006350914050169

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