Skip to main content
Log in

Myelination disorders in the mechanism of hypogravity motor syndrome development

Biophysics Aims and scope Submit manuscript

Abstract

When modeling the effects of hypogravity by the method of hindlimb unloading in rats, the area of cross-section in the lumbar part of spinal cord was found to reduce. Analysis of spinal cord slides showed that these changes are associated with a decrease in the area of white substance. The data obtained are consistent with our previous observation of a decrease in expression of the genes encoding myelin proteins. The results of our research give good reasons to believe that myelination failure in CNS is one of the factors that underlie the development of the hypogravity motor syndrome.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. A. I. Grigor’ev, I. B. Kozlovskaya, and B. S. Shenkman, Ross. Fiziol. Zh. im. Sechenova 90(5), 508 (2004).

    Google Scholar 

  2. A. I. Grigor’ev and B. S. Shenkman, Vestn. RAN 78(4), 337 (2008).

    Google Scholar 

  3. E. R. Morey-Holton and K. Globus, J. Appl. Physiol. 92, 1367 (2002).

    Article  Google Scholar 

  4. R. R. Islamov, E. A. Mishagina, et al., Acta Astronautica 68, 1469 (2011).

    Article  ADS  Google Scholar 

  5. A. M. Genin, A. E. Il’in, A. S. Kaplanskii, et al., Aviakosm Ekol. Med. 4, 14 (2011).

    Google Scholar 

  6. R. R. Islamov, A. A. Rizvanov, O. V. Tyapkina, et al., Dokl. RAN 439(3), 1 (2011).

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to O. V. Tyapkina.

Additional information

Original Russian Text © O.V. Tyapkina, L.F. Nurullin, P.N. Rezvyakov, I.B. Kozlovskaya, E.E. Nikolsky, R.R. Islamovb, 2012, published in Biofizika, 2012, Vol. 57, No. 5, pp. 876–879.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Tyapkina, O.V., Nurullin, L.F., Rezvyakov, P.N. et al. Myelination disorders in the mechanism of hypogravity motor syndrome development. BIOPHYSICS 57, 681–683 (2012). https://doi.org/10.1134/S0006350912050223

Download citation

  • Received:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1134/S0006350912050223

Keywords

Navigation