Biochemistry (Moscow)

, Volume 76, Issue 3, pp 283-294

First online:

Eukaryotic type translation initiation factor 2: Structure–functional aspects

  • E. A. StolboushkinaAffiliated withInstitute of Protein Research, Russian Academy of Sciences Email author 
  • , M. B. GarberAffiliated withInstitute of Protein Research, Russian Academy of Sciences

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Translation initiation factor 2 (IF2) is one of key components of the translation initiation system in living cells. In bacteria IF2 is a multidomain monomeric protein, while in eukaryotic and archaean cells e/aIF2 is heterotrimer (αβγ). Data, including our own, on eukaryotic type translation initiation factor 2 (e/aIF2) structure and functioning are presented. There are also new data on initiation factors eIF5 and eIF2B that directly interact with eIF2 and control its participation in nucleotide exchange.

Key words

translation initiation e/aIF2 heterotrimer initiator methionyl-tRNA (Met-tRNAi) Met-tRNAi·e/aIF2·GTP triple complex