Biochemistry (Moscow)

, Volume 76, Issue 3, pp 283–294

Eukaryotic type translation initiation factor 2: Structure–functional aspects

Review

DOI: 10.1134/S0006297911030011

Cite this article as:
Stolboushkina, E.A. & Garber, M.B. Biochemistry Moscow (2011) 76: 283. doi:10.1134/S0006297911030011

Abstract

Translation initiation factor 2 (IF2) is one of key components of the translation initiation system in living cells. In bacteria IF2 is a multidomain monomeric protein, while in eukaryotic and archaean cells e/aIF2 is heterotrimer (αβγ). Data, including our own, on eukaryotic type translation initiation factor 2 (e/aIF2) structure and functioning are presented. There are also new data on initiation factors eIF5 and eIF2B that directly interact with eIF2 and control its participation in nucleotide exchange.

Key words

translation initiatione/aIF2heterotrimerinitiator methionyl-tRNA (Met-tRNAi)Met-tRNAi·e/aIF2·GTP triple complex

Abbreviations

a.a.

amino acid residue

CTD

C-terminal domain

ds

double-stranded

HCV

hepatitis C virus

IF2

translation initiation factor

MFC

multifactor complex

NTD

N-terminal domain

Pi

inorganic phosphate

Copyright information

© Pleiades Publishing, Ltd. 2011

Authors and Affiliations

  1. 1.Institute of Protein ResearchRussian Academy of SciencesPushchino, Moscow RegionRussia