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An overview on nucleases (DNase, RNase, and phosphodiesterase) in snake venoms

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Abstract

In this review, we have compiled the data on pharmacological activities associated with endogenous purine release related enzymes—nucleases (DNases, RNases, and phosphodiesterases). The results of studies on toxic effects of these enzymes, emphasizing the future directions in this field, are summarized. One of the major problems facing toxicologists is the identification and characterization of specific venom nucleases since they share similar substrate specificities and biochemical properties. In this review, we have attempted to clarify some of the discrepancies about these enzymes. Further, we have tried to correlate the existence of nuclease enzymes in relation to endogenous release of purines, a multitoxin, during snake envenomation, and we also discuss the possible actions of purines. We hope that this review will stimulate renewed interest among toxicologists to biologically characterize these enzymes and elucidate their role in envenomation.

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Abbreviations

EST:

expressed sequence tag

PDE:

phosphodiesterase

PLA2 :

phospholipase A2

References

  1. Bieber, A. L. (1979) in Snake Venoms, Handbook of Experimental Pharmacology (Lee, C. Y., ed.) Springer-Verlag, Berlin, pp. 295–306.

    Google Scholar 

  2. Aird, S. D. (2002) Toxicon, 40, 335–393.

    Article  CAS  PubMed  Google Scholar 

  3. Aird, S. D. (2005) Comp. Biochem. Physiol. B Biochem. Mol. Biol., 140, 109–126.

    Article  PubMed  Google Scholar 

  4. Chippaux, J. P., Williams, V., and White, J. (1991) Toxicon, 29, 1279–1303.

    Article  CAS  PubMed  Google Scholar 

  5. Williams, V., and White, J. (1992) Toxicon, 30, 202–206.

    Article  CAS  PubMed  Google Scholar 

  6. Mirtschin, P. J., Shine, R., Nias, T. J., Dunstan, N. L., Hough, B. J., and Mirtschin, M. (2002) Toxicon, 40, 1581–1592.

    Article  CAS  PubMed  Google Scholar 

  7. Saravia, P., Rojas, E., Arce, V., Guevara, C., Lopez, J. C., Chaves, E., Velasquez, R., Rojas, G., and Gutierrez, J. M. (2002) Rev. Biol. Trop., 50, 337–346.

    PubMed  Google Scholar 

  8. Shashidharamurthy, R., Jagadeesha, D. K., Girish, K. S., and Kemparaju, K. (2002) Mol. Cell Biochem., 229, 93–101.

    Article  CAS  PubMed  Google Scholar 

  9. Jorge da Silva, N. Jr., and Aird, S. D. (2001) Comp. Biochem. Physiol. C Toxicol. Pharmacol., 128, 425–456.

    Article  PubMed  Google Scholar 

  10. Urdaneta, A. H., Bolanos, F., and Gutierrez, J. M. (2004) Comp. Biochem. Physiol. C Toxicol. Pharmacol., 138, 485–492.

    Article  PubMed  Google Scholar 

  11. Pawlak, J., Mackessy, S. P., Fry, B. G., Bhatia, M., Mourier, G., Fruchart-Gaillard, C., Servent, D., Menez, R., Stura, E., Menez, A., and Kini, R. M. (2006) J. Biol. Chem., 281, 29030–29041.

    Article  CAS  PubMed  Google Scholar 

  12. Kochva, E. (1987) Toxicon, 25, 65–106.

    Article  CAS  PubMed  Google Scholar 

  13. Fry, B. G. (2005) Genome Res., 15, 403–420.

    Article  CAS  PubMed  Google Scholar 

  14. Kini, R. M. (1997) in Venom Phospholipase A2 Enzymes: Structure, Function and Mechanism (Kini, R. M., ed.) John Wiley and Sons, New York, pp. 1–28.

    Google Scholar 

  15. Gutierrez, J. M., and Rucavado, A. (2000) Biochimie, 82, 841–850.

    Article  CAS  PubMed  Google Scholar 

  16. Iwanaga, S., and Suzuki, T. (1979) in Snake Venoms, Handbook of Experimental Pharmacology (Lee, C. Y., ed.) Springer-Verlag, Berlin, pp. 61–158.

    Google Scholar 

  17. Mackessy, S. P. (1998) in Enzymes from Snake Venoms (Bailey, G. S., ed.) Alaken Press, Ft. Collins, pp. 361–404.

    Google Scholar 

  18. Lumsden, N. G., Fry, B. G., Ventura, S., Kini, R. M., and Hodgson, W. C. (2004) Auton. Autacoid. Pharmacol., 24, 107–113.

    Article  CAS  PubMed  Google Scholar 

  19. Ralevic, V., and Burnstock, G., (1998) Pharmacol. Rev., 50, 413–492.

    CAS  PubMed  Google Scholar 

  20. Burnstock, G. (2006) Novartis Found. Symp., 276, 26–48.

    Article  CAS  PubMed  Google Scholar 

  21. Sawynok, J. (2007) Handb. Exp. Pharmacol., 177, 309–328.

    Article  CAS  PubMed  Google Scholar 

  22. Mori, N., Nikai, T., and Sugihara, H. (1987) Int. J. Biochem., 19, 115–119.

    Article  CAS  PubMed  Google Scholar 

  23. Stoynov, S. S., Bakalova, A. T., Dimov, S. I., Mitkova, A. V., and Dolapchiev, L. B. (1997) FEBS Lett., 409, 151–154.

    Article  CAS  PubMed  Google Scholar 

  24. Delezenne, C., and Morel, H. (1919) Compt. Rend. Acad., 168, 241.

    Google Scholar 

  25. Sittenfeld, A. H., Raventos, Cruz, R., and Gutirrez, J. M. (1991) Toxicon, 29, 213–224.

    Article  Google Scholar 

  26. De Roodt, A. R., Litwin, S., and Angel, S. O. (2003) Comp. Biochem. Physiol. C Toxicol. Pharmacol., 135, 469–479.

    Article  PubMed  Google Scholar 

  27. Georgatsos, J. G., and Laskowski, M. Sr. (1962) Biochemistry, 1, 288–295.

    Article  CAS  PubMed  Google Scholar 

  28. Vassilenko, S. K., and Babkina, G. T. (1965) Biokhimiya, 30, 705–712.

    Google Scholar 

  29. Vassilenko, S. K., and Ryte, V. C. (1975) Biokhimiya, 40, 578–583.

    Google Scholar 

  30. Mahalakshmi, Y. V., and Pandit, M. W. (1987) Biochem. Biophys. Res. Commun., 145, 740–748.

    Article  CAS  PubMed  Google Scholar 

  31. Mahalakshmi, Y. V., Jagannadham, M. V., and Pandit, M. W. (2000) IUBMB Life, 49, 309–316.

    Article  CAS  PubMed  Google Scholar 

  32. Laskowski, M. Sr. (1980) Meth. Enzymol., 65, 276–284.

    Article  CAS  PubMed  Google Scholar 

  33. Uzawa, S. (1932) J. Biochem., 15, 19.

    CAS  Google Scholar 

  34. Mackessy, S. P., and Tu, A. T. (1993) in Toxicon-Related Diseases: Poisons Originating from Plants, Animals, and Spoilage (Tu, A. T., ed.) Oxford/IBH Press, New Delhi, pp. 305–351.

    Google Scholar 

  35. Philipps, G. R. (1976) Biochim. Biophys. Acta, 432, 237–244.

    CAS  PubMed  Google Scholar 

  36. Perron, S., Mackessy, S. P., and Hyslop, R. M. (1993) J. Colo.-Wyo. Acad. Sci., 25, 21–22.

    Google Scholar 

  37. Mackessy, S. P. (1989) PhD Dissertation, Washington State University.

  38. Kini, R. M., and Gowda, T. V. (1984) J. Chromatogr., 291, 299–305.

    Article  CAS  PubMed  Google Scholar 

  39. Francis, B., Seebart, C., and Kaiser, I. I. (1992) Toxicon, 30, 1239–1246.

    Article  CAS  PubMed  Google Scholar 

  40. Freitas, M. A., Geno, P. W., Sumner, L. W., Cooke, M. E., Hudiburg, S. A., Ownby, C. L., Kaiser, I. I., and Odell, G. V. (1992) Toxicon, 30, 461–464.

    Article  CAS  PubMed  Google Scholar 

  41. Sugihara, H., Nikai, T., Naruse, M., Kishida, M., and Mori, N. (1986) Int. J. Biochem., 18, 203–207.

    Article  CAS  PubMed  Google Scholar 

  42. Valerio, A. A., Corradini, A. C., Panunto, P. C., Mello, S. M., and Hyslop, S. (2002) J. Prot. Chem., 21, 495–503.

    Article  CAS  Google Scholar 

  43. Dolapchiev, L. B., Vassileva, R. A., and Koumanov, K. S. (1980) Biochim. Biophys. Acta, 622, 331–336.

    CAS  PubMed  Google Scholar 

  44. Levy, Z., and Bdolah, A. (1976) Toxicon, 14, 389–391.

    Article  CAS  PubMed  Google Scholar 

  45. Junqueirs-de-Azevedo, I. L., Ching, A. T., Carvalho, E., Faria, F., Nishiyama, M. Y., Jr., Ho, P. L., and Diniz, M. R. (2006) Genetics, 173, 877–889.

    Article  Google Scholar 

  46. Oinghua, L., Xiaowei, Z., Wei, Y., Chenji, L., Yijun, H., Penaxin, Q., Xingwen, S., Songnin, H., and Guangmei, Y. (2006) Biochem. Biophys. Res. Commun., 341, 522–531.

    Article  Google Scholar 

  47. Pahari, S., Mackessy, S. P., and Kini, R. M. (2007) BMC Mol. Biol., 8, 115.

    Article  PubMed  Google Scholar 

  48. Russell, F. E., Buess, F. W., and Woo, M. Y. (1963) Toxicon, 1, 99–108.

    Article  CAS  Google Scholar 

  49. Halim, H. Y., Shaban, E. A., Hagag, M. M., Daoud, E. W., and El-Asmar, M. F. (1987) Toxicon, 25, 1199–1207.

    Article  CAS  PubMed  Google Scholar 

  50. Philipps, G. R. (1975) Hoppe-Seylers Z. Physiol. Chem., 356, 1085–1096.

    CAS  PubMed  Google Scholar 

  51. Ownby, C. L., Bjarnason, J., and Tu, A. T. (1978) Am. J. Pathol., 93, 201–218.

    CAS  PubMed  Google Scholar 

  52. Bernheimer, A. W., and Rudy, B. (1986) Biochim. Biophys. Acta, 864, 123–141.

    CAS  PubMed  Google Scholar 

  53. Nunez, C. E., Angulo, Y., and Lomonte, B. (2001) Toxicon, 39, 1587–1594.

    Article  CAS  PubMed  Google Scholar 

  54. Ma, D., Armugam, A., and Jeyaseelan, K. (2002) Biochem. J., 366, 35–43.

    CAS  PubMed  Google Scholar 

  55. Hargreaves, M. B., Stoggall, S. M., and Collis, M. G. (1991) Br. J. Pharmacol., 102, 198.

    Google Scholar 

  56. Sobrevia, L., Yudilevich, D. L., and Mann, G. E. (1997) J. Physiol., 499, 135–140.

    CAS  PubMed  Google Scholar 

  57. Seligmann, C., Kupatt, C., Becker, B. F., Zahler, S., and Beblo, S. (1998) J. Cardiovasc. Pharmacol., 32, 156–163.

    Article  CAS  PubMed  Google Scholar 

  58. Ramkumar, V., Stiles, G. L., Beaven, M. A., and Ali, H. (1993) J. Biol. Chem., 268, 16887–16890.

    CAS  PubMed  Google Scholar 

  59. Redman, R. S., and Silinsky, E. M. (1993) Mol. Pharmacol., 44, 835–840.

    CAS  PubMed  Google Scholar 

  60. Olsson, R. A., and Pearson, J. D. (1990) Physiol. Rev., 70, 761–845.

    CAS  PubMed  Google Scholar 

  61. Castrop, H. (2007) Acta Physiol. (Oxford), 189, 3–14.

    CAS  Google Scholar 

  62. Dunwiddie, T. V., and Worth, T. (1982) J. Pharmacol. Exp. Ther., 220, 70–76.

    CAS  PubMed  Google Scholar 

  63. Barraco, R. A., Coffin, V. L., Altman H. J., and Phillips, J. W. (1983) Brain Res., 272, 392–395.

    Article  CAS  PubMed  Google Scholar 

  64. Winsky, L., and Harvey, J. A. (1986) J. Neurosci., 6, 2684–2690.

    CAS  PubMed  Google Scholar 

  65. Palmour, R. M., Lipowski, C. J., Simon, C. K., and Ervin, F. R. (1989) Life Sci., 44, 1293–1301.

    Article  CAS  PubMed  Google Scholar 

  66. Nikodijevic, O., Sarges, R., Daly, J. W., and Jacobson, K. A. (1991) J. Pharmacol. Exp. Ther., 259, 286–294.

    CAS  PubMed  Google Scholar 

  67. Jain, N., Kemp, N., Adeyeno, O., Buchanan, P., and Stone, T. W. (1995) Br. J. Pharmacol., 116, 2127–2133.

    CAS  PubMed  Google Scholar 

  68. Sawynok, J., Zarrindast, M. R., Reid, A. R., and Doak, G. J. (1997) Eur. J. Pharmacol., 333, 1–7.

    Article  CAS  PubMed  Google Scholar 

  69. Sawynok, J. (1998) Eur. J. Pharmacol., 347, 1–11.

    Article  CAS  PubMed  Google Scholar 

  70. Dhananjaya, B. L., Nataraju, A., Rajesh, R., Raghavendra Gowda, C. D., Sharath, B. K., Vishwanath, B. S., and D’souza, C. J. (2006) Toxicon, 48, 411–421.

    Article  CAS  PubMed  Google Scholar 

  71. Tilley, S. L., Wagoner, V. A., Salvatore, C. A., Jacobson, M. A., and Koller, B. H. (2000) J. Clin. Invest., 105, 361–367.

    Article  CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Studies in Biochemistry, University of Mysore, Manasagangothri, Mysore, 570006, India

    B. L. Dhananjaya & C. J. M. D’souza

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  1. B. L. Dhananjaya
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  2. C. J. M. D’souza
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Correspondence to C. J. M. D’souza.

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Published in Russian in Biokhimiya, 2010, Vol. 75, No. 1, pp. 5–11.

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Dhananjaya, B.L., D’souza, C.J.M. An overview on nucleases (DNase, RNase, and phosphodiesterase) in snake venoms. Biochemistry Moscow 75, 1–6 (2010). https://doi.org/10.1134/S0006297910010013

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