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Mechanisms of single-stranded DNA-binding protein functioning in cellular DNA metabolism

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Abstract

This review deals with analysis of mechanisms involved in coordination of DNA replication and repair by SSB proteins; characteristics of eukaryotic, prokaryotic, and archaeal SSB proteins are considered, which made it possible to distinguish general mechanisms specific for functioning of proteins from organisms of different life domains. Mechanisms of SSB protein interactions with DNA during metabolism of the latter are studied; structural organization of the SSB protein complexes with DNA, as well as structural and functional peculiarities of different SSB proteins are analyzed.

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Abbreviations

a.a.:

amino acid residues

dsDNA:

double-stranded DNA

ecoSSB:

Escherichia coli SSB

hsRPA:

Homo sapiens RPA

NER:

nucleotide excision repair

nt:

nucleotide

OB domain:

oligosaccharide/oligonucleotide-binding domain

PCNA:

proliferating cell nuclear antigen

pol-prim:

DNA polymerase α-primase complex

RFC:

replication factor C

RPA:

replication protein A

SSB:

single-stranded DNA-binding protein

ssDNA:

single-stranded DNA

References

  1. Wold, M. S. (1997) Annu. Rev. Biochem., 66, 61–92.

    Article  PubMed  CAS  Google Scholar 

  2. Lohman, T. M., and Ferrari M. E. (1994) Annu. Rev. Biochem., 63, 527–570.

    PubMed  CAS  Google Scholar 

  3. Cha, T. A., and Alberts, B. M. (1989) J. Biol. Chem., 264, 12220–12225.

    PubMed  CAS  Google Scholar 

  4. Kim, Y. T., and Richardson, C. C. (1993) Proc. Natl. Acad. Sci. USA, 90, 10173–10177.

    Article  PubMed  CAS  Google Scholar 

  5. Perales, C., Cava, F., and Meijer, W. J. J. (2003) Nucleic Acids Res., 31, 6473–6380.

    Article  PubMed  CAS  Google Scholar 

  6. Chase, J. W., and Williams, K. R. (1986) Annu. Rev. Biochem., 55, 103–136.

    Article  PubMed  CAS  Google Scholar 

  7. Zou, Y., Liu, Y., Wu, X., and Shell, S. M. (2006) J. Cell. Physiol., 208, 267–273.

    Article  PubMed  CAS  Google Scholar 

  8. Stein, G. S., Zaidi, S. K., Braastad, C. D., Montecino, M., van Wijnen, A. J., Choi, J. Y., Stein, J. L., Lian, J. B., and Javed, A. (2003) Trends Cell. Biol., 13, 584–592.

    Article  PubMed  CAS  Google Scholar 

  9. Davey, M. J., and O’Donnell, M. (2000) Curr. Opin. Chem. Biol., 4, 581–586.

    Article  PubMed  CAS  Google Scholar 

  10. Kur, J., Olszewski, M., Dlugolecka, A., and Filipkowski, P. (2005) Acta Biochim. Pol., 52, 569–574.

    PubMed  CAS  Google Scholar 

  11. Yuzhakov, A., Kelman, Z., Hurwitz, J., and O’Donnell, M. (1999) EMBO J., 18, 6189–6199.

    Article  PubMed  CAS  Google Scholar 

  12. Maga, G., Stucki, M., Spadari, S., and Hubscher, U. (2000) J. Mol. Biol., 295, 791–801.

    Article  PubMed  CAS  Google Scholar 

  13. Carty, M. P., Levine, A. S., and Dixon, K. (1992) Mutat. Res., 274, 29–34.

    PubMed  CAS  Google Scholar 

  14. Maga, G., Frouin, I., Spadari, S., and Hubscher, U. (2001) J. Biol. Chem., 276, 18235–18242.

    Article  PubMed  CAS  Google Scholar 

  15. Robbins, J. B., Murphy, M. C., White, B. A., Mackie, R. I., Ha, T., and Cann, I. K. (2004) J. Biol. Chem., 279, 6315–6326.

    Article  PubMed  CAS  Google Scholar 

  16. Cann, I. K., Ishino, S., Yuasa, M., Daiyasu, H., Toh, H., and Ishino, Y. (2001) J. Bacteriol., 183, 2614–2623.

    Article  PubMed  CAS  Google Scholar 

  17. Robbins, J. B., McKinney, M. C., Guzman, C. E., Sriratana, B., Fitz-Gibbon, S., Ha, T., and Cann, I. K. (2005) J. Biol. Chem., 280, 15325–15339.

    Article  PubMed  CAS  Google Scholar 

  18. Kelman, Z., Pietrokovski, S., and Hurwitz, J. (1999) J. Biol. Chem., 274, 28751–28761.

    Article  PubMed  CAS  Google Scholar 

  19. Stauffer, M. E., and Chazin, W. J. (2004) J. Biol. Chem., 279, 30915–30918.

    Article  PubMed  CAS  Google Scholar 

  20. Benkovic, S. J., Valentine, A. M., and Salinas, F. (2001) Annu. Rev. Biochem., 70, 181–208.

    Article  PubMed  CAS  Google Scholar 

  21. Khlimankov, D. Yu., Rechkunova, N. A., and Lavrik, O. I. (2004) Biochemistry (Moscow), 69, 248–261.

    Article  CAS  Google Scholar 

  22. Rademakers, S., Volker, M., Hoogstraten, D., Nigg, A. L., Mone, M. J., van Zeeland, A. A., Hoeijmakers, J. H., Houtsmuller, A. B., and Vermeulen, W. (2003) Mol. Cell. Biol., 23, 5755–5767.

    Article  PubMed  CAS  Google Scholar 

  23. Essers, J., Houtsmuller, A. B., van Veelen, L., Paulusma, C., Nigg, A. L., Pastink, A., Vermeulen, W., Hoeijmakers, J. H., and Kanaar, R. (2002) EMBO J., 21, 2030–2037.

    Article  PubMed  CAS  Google Scholar 

  24. Arunkumar, A. I., Stauffer, M. E., Bochkareva, E., Bochkarev, A., and Chazin, W. J. (2003) J. Biol. Chem., 17, 41077–41082.

    Article  CAS  Google Scholar 

  25. Murzin, A. G., Brenner, S. E., Hubbard, T., and Chothia, C. (1995) J. Mol. Biol., 247, 536–540.

    PubMed  CAS  Google Scholar 

  26. Murzin, A. G. (1993) EMBO J., 12, 861–867.

    PubMed  CAS  Google Scholar 

  27. Theobald, D. L., Mitton-Fry, R. M., and Wuttke, D. S. (2003) Annu. Rev. Biophys. Biomol. Struct., 32, 115–133.

    Article  PubMed  CAS  Google Scholar 

  28. Williams, K. R., Spicer, E. K., LoPresti, M. B., Guggenheimer, R. A., and Chase, J. W. (1983) J. Biol. Chem., 258, 3346–3355.

    PubMed  CAS  Google Scholar 

  29. Carlini, L., Curth, U., Kindler, B., Urbanke, C., and Porter, R. D. (1998) FEBS Lett., 430, 197–200.

    Article  PubMed  CAS  Google Scholar 

  30. Iftode, C., Daniely, Y., and Borowiec, J. A. (1999) Crit. Rev. Biochem. Mol. Biol., 34, 141–180.

    Article  PubMed  CAS  Google Scholar 

  31. Bochkareva, E., Korolev, S., Lees-Miller, S. P., and Bochkarev, A. (2002) EMBO J., 21, 1855–1863.

    Article  PubMed  CAS  Google Scholar 

  32. Daughdrill, G. W., Buchko, G. W., Botuyan, M. V., Arrowsmith, C., Wold, M. S., Kennedy, M. A., and Lowry, D. F. (2003) Nucleic Acids Res., 31, 4176–4183.

    Article  PubMed  CAS  Google Scholar 

  33. Weisshart, K., Taneja, P., and Fanning, E. (1998) J. Virol., 72, 9771–9781.

    PubMed  CAS  Google Scholar 

  34. Golub, E. I., Gupta, R. C., Haaf, T., Wold, M. S., and Radding, C. M. (1998) Nucleic Acids Res., 26, 5388–5393.

    Article  PubMed  CAS  Google Scholar 

  35. Bochkareva, E., Kaustov, L., Ayed, A., Yi, G. S., Lu, Y., Pineda-Lucena, A., Liao, J. C., Okorokov, A. L., Milner, J., Arrowsmith, C. H., and Bochkarev, A. (2005) Proc. Natl. Acad. Sci. USA, 102, 15412–15417.

    Article  PubMed  CAS  Google Scholar 

  36. Daughdrill, G. W., Ackerman, J., Isern, N. G., Botuyan, M. V., Arrowsmith, C., Wold, M. S., and Lowry, D. F. (2001) Nucleic Acids Res., 29, 3270–3276.

    Article  PubMed  CAS  Google Scholar 

  37. He, Z., Brinton, B. T., Greenblatt, J., Hassell, J. A., and Ingles, C. J. (1993) Cell, 73, 1223–1232.

    Article  PubMed  CAS  Google Scholar 

  38. Mer, G., Bochkarev, A., Gupta, R., Bochkareva, E., Frappier, L., Ingles, C. J., Edwards, A. M., and Chazin, W. J. (2000) Cell, 103, 449–456.

    Article  PubMed  CAS  Google Scholar 

  39. Gajiwala, K. S., and Burley, S. K. (2000) Curr. Opin. Struct. Biol., 10, 110–116.

    Article  PubMed  CAS  Google Scholar 

  40. Braun, K. A., Lao, Y., He, Z., Ingles, C. J., and Wold, M. S. (1997) Biochemistry, 36, 8443–8454.

    Article  PubMed  CAS  Google Scholar 

  41. Stauffer, M. E., and Chazin, W. J. (2004) J. Biol. Chem., 279, 25638–25645.

    Article  PubMed  CAS  Google Scholar 

  42. Kelly, T. J., Simancek, P., and Brush, G. S. (1998) Proc. Natl. Acad. Sci. USA, 95, 14634–14639.

    Article  PubMed  CAS  Google Scholar 

  43. Philipova, D., Mullen, J. R., Maniar, H. S., Lu, J., Gu, C., and Brill, S. J. (1996) Genes Dev., 10, 2222–2233.

    Article  PubMed  CAS  Google Scholar 

  44. De Vries, J., and Wackernagel, W. (1993) Gene, 127, 39–45.

    Article  PubMed  Google Scholar 

  45. Genschel, J., Litz, L., Thole, H., Roemling, U., and Urbanke, C. (1996) Gene, 182, 137–143.

    Article  PubMed  Google Scholar 

  46. Purnapatre, K., and Varshney, U. (1999) Eur. J. Biochem., 264, 591–598.

    Article  PubMed  CAS  Google Scholar 

  47. Sancar, A., Williams, K., Chase, J., and Rupp, W. (1981) Proc. Natl. Acad. Sci. USA, 78, 4274–4278.

    Article  PubMed  CAS  Google Scholar 

  48. Weiner, J. H., Bertsch, L. L., and Kornberg, A. (1975) J. Biol. Chem., 250, 1972–1980.

    PubMed  CAS  Google Scholar 

  49. Webster, G., Genschel, J., Curth, U., Urbanke, C., Kang, C., and Hilgenfeld, R. (1997) FEBS Lett., 411, 313–316.

    Article  PubMed  CAS  Google Scholar 

  50. Yang, C., Curth, U., Urbanke, C., and Kang, C.-H. (1997) Nat. Struct. Biol., 4, 153–157.

    Article  PubMed  CAS  Google Scholar 

  51. Curth, U., Urbanke, C., Greipel, J., Gerberding, H., Tiranti, V., and Zeviani, M. (1994) Eur. J. Biochem., 221, 435–443.

    Article  PubMed  CAS  Google Scholar 

  52. Dabrowski, S., Olszewski, M., Piatek, R., Brillowska-Dabrowska, A., Konopa, G., and Kur, J. (2002) Microbiology, 148, 3307–3315.

    PubMed  CAS  Google Scholar 

  53. Eggington, J. M., Haruta, N., Wood, E. A., and Cox, M. M. (2004) BMC Microbiol., 4, 2.

    Article  PubMed  Google Scholar 

  54. Witte, G., Urbanke, C., and Curth, U. (2005) Nucleic Acids Res., 33, 1662–1670.

    Article  PubMed  CAS  Google Scholar 

  55. Bernstein, D. A., Eggington, J. M., Killoran, M. P., Misic, A. M., Cox, M. M., and Keck, J. L. (2004) Proc. Natl. Acad. Sci. USA, 101, 8575–8580.

    Article  PubMed  CAS  Google Scholar 

  56. Bochkarev, A., Pfuetzner, R. A., Edwards, A. M., and Frappier, L. (1997) Nature, 385, 176–181.

    Article  PubMed  CAS  Google Scholar 

  57. Lin, Y., Robbins, J. B., Nyannor, E. K., Chen, Y. H., and Cann, I. K. (2005) J. Bacteriol., 187, 7881–7889.

    Article  PubMed  CAS  Google Scholar 

  58. Lin, Y. L., Shivji, K. K., Chen, C., Kolodner, R., Wood, R. D., and Dutta, A. (1998) J. Biol. Chem., 273, 1453–1461.

    Article  PubMed  CAS  Google Scholar 

  59. Bochkareva, E., Frappier, L., Edwards, A. M., and Bochkarev, A. (1998) J. Biol. Chem., 273, 3932–3936.

    Article  PubMed  CAS  Google Scholar 

  60. Bochkarev, A., Bochkareva, E., Frappier, L., and Edwards, A. M. (1999) EMBO J., 18, 4498–4504.

    Article  PubMed  CAS  Google Scholar 

  61. Chedin, F., Seitz, E. M., and Kowalczykowski, S. C. (1998) Trends Biochem. Sci., 23, 273–277.

    Article  PubMed  CAS  Google Scholar 

  62. Kerr, I. D., Wadsworth, R. I., Cubeddu, L., Blankenfeldt, W., Naismith, J. H., and White, M. F. (2003) EMBO J., 22, 2561–2570.

    Article  PubMed  CAS  Google Scholar 

  63. Wadsworth, R. I., and White, M. F. (2001) Nucleic Acids Res., 29, 914–920.

    Article  PubMed  CAS  Google Scholar 

  64. Bochkarev, A., and Bochkareva, E. (2004) Curr. Opin. Struct. Biol., 14, 36–42.

    Article  PubMed  CAS  Google Scholar 

  65. Raghunathan, S., Ricard, C. S., Lohman, T. M., and Waksman, G. (1997) Proc. Natl. Acad. Sci. USA, 94, 6652–6657.

    Article  PubMed  CAS  Google Scholar 

  66. Raghunathan, S., Kozlov, A. G., Lohman, T. M., and Waksman, G. (2000) Nat. Struct. Biol., 7, 648–652.

    Article  PubMed  CAS  Google Scholar 

  67. Antson, A. A. (2000) Curr. Opin. Struct. Biol., 10, 87–94.

    Article  PubMed  CAS  Google Scholar 

  68. Berman, H. M., Westbrook, J., Feng, Z., Gilliland, G., Bhat, T. N., Weissig, H., Shindyalov, I. N., and Bourne, P. E. (2000) Nucleic Acids Res., 28, 235–242.

    Article  PubMed  CAS  Google Scholar 

  69. Carter, A. P., Clemons, W. M., Jr., Brodersen, D. E., Morgan-Warren, R. J., Hartsch, T., Wimberly, B. T., and Ramakrishnan, V. (2001) Science, 291, 498–501.

    Article  PubMed  CAS  Google Scholar 

  70. Bochkareva, E., Belegu, V., Korolev, S., and Bochkarev, A. (2001) EMBO J., 20, 612–618.

    Article  PubMed  CAS  Google Scholar 

  71. Bogden, C. E., Fass, D., Bergman, N., Nichols, M. D., and Berger, J. M. (1999) Mol. Cell, 3, 487–493.

    Article  PubMed  CAS  Google Scholar 

  72. Peersen, O. B., Ruggles, J. A., and Schultz, S. C. (2002) Nat. Struct. Biol., 9, 182–187.

    PubMed  CAS  Google Scholar 

  73. Savvides, S. N., Raghunathan, S., Futterer, K., Kozlov, A. G., Lohman, T. M., and Waksman, G. (2004) Protein Sci., 13, 1942–1947.

    Article  PubMed  CAS  Google Scholar 

  74. Grishin, N. V. (2001) Nucleic Acids Res., 29, 1703–1714.

    Article  PubMed  CAS  Google Scholar 

  75. Matthews, J. M., and Sunde, M. (2002) IUBMB Life, 54, 351–355.

    Article  PubMed  CAS  Google Scholar 

  76. Krishna, S. S., Majumdar, I., and Grishin, N. V. (2003) Nucleic Acids Res., 31, 532–550.

    Article  PubMed  CAS  Google Scholar 

  77. Lachenmann, M. J., Ladbury, J. E., Dong, J., Huang, K., Carey, P., and Weiss, M. A. (2004) Biochemistry, 43, 13910–13925.

    Article  PubMed  CAS  Google Scholar 

  78. Park, J. S., Wang, M., Park, S. J., and Lee, S. H. (1999) J. Biol. Chem., 274, 29075–29080.

    Article  PubMed  CAS  Google Scholar 

  79. Komori, K., and Ishino, Y. (2001) J. Biol. Chem., 276, 25654–25660.

    Article  PubMed  CAS  Google Scholar 

  80. Bochkareva, E., Korolev, S., and Bochkarev, A. (2000) J. Biol. Chem., 275, 27332–27338.

    PubMed  CAS  Google Scholar 

  81. Bujalowski, W., Overman, L. B., and Lohman, T. M. (1988) J. Biol. Chem., 163, 4629–4640.

    Google Scholar 

  82. Kozlov, A. G., and Lohman, T. M. (2002) Biochemistry, 41, 11611–11627.

    Article  PubMed  CAS  Google Scholar 

  83. Bastin-Shanower, S. A., and Brill, S. J. (2001) J. Biol. Chem., 276, 36446–36453.

    Article  PubMed  CAS  Google Scholar 

  84. Lavrik, O. I., Kolpashchikov, D. M., Weisshart, K., Nasheuer, H. P., Khodyreva, S. N., and Favre, A. (1999) Nucleic Acids Res., 27, 4235–4240.

    Article  PubMed  CAS  Google Scholar 

  85. Gomes, X. V., Henricksen, L. A., and Wold, M. S. (1996) Biochemistry, 35, 5586–5595.

    Article  PubMed  CAS  Google Scholar 

  86. Pestryakov, P. E., Weisshart, K., Schlott, B., Khodyreva, S. N., Kremmer, E., Grosse, F., Lavrik, O. I., and Nasheuer, H.-P. (2003) J. Biol. Chem., 278, 17515–17524.

    Article  PubMed  CAS  Google Scholar 

  87. Pestryakov, P. E., Krasikova, Yu. S., Petruseva, I. O., Khodyreva, S. N., and Lavrik, O. I. (2007) Dokl. AN SSSR, 412, 118–122.

    Google Scholar 

  88. De Laat, W. L., Appeldoorn, E., Sugasawa, K., Weterings, E., Jaspers, N. G., and Hoeijmakers, J. H. (1998) Genes Dev., 12, 2598–2609.

    Article  PubMed  Google Scholar 

  89. Treuner, K., Ramsperger, U., and Knippers, R. J. (1996) Mol. Biol., 259, 104–112.

    Article  CAS  Google Scholar 

  90. Blackwell, L. J., Borowiec, J. A., and Masrangelo, I. A. (1996) Mol. Cell. Biol., 16, 4798–4807.

    PubMed  CAS  Google Scholar 

  91. Lohman, T. M., and Overman, L. B. (1985) J. Biol. Chem., 260, 3594–3603.

    PubMed  CAS  Google Scholar 

  92. Kim, C., and Wold, M. S. (1995) Biochemistry, 34, 2058–2064.

    Article  PubMed  CAS  Google Scholar 

  93. Brill, S. J., and Stillman, B. (1991) Genes Dev., 5, 1589–1600.

    Article  PubMed  CAS  Google Scholar 

  94. Heyer, W.-D., Rao, M. R. S., Erdile, L. F., Kelly, T. J., and Kolodner, R. D. (1990) EMBO J., 9, 2321–2329.

    PubMed  CAS  Google Scholar 

  95. Kolpashchikov, D. M., Khodyreva, S. N., Khlimankov, D. Y., Wold, M. S., Favre, A., and Lavrik, O. I. (2001) Nucleic Acids Res., 29, 373–379.

    Article  PubMed  CAS  Google Scholar 

  96. Pestryakov, P. E., Khlimankov, D. Yu., Bochkareva, E., Bochkarev, A., and Lavrik, O. I. (2004) Nucleic Acids Res., 32, 1894–1903.

    Article  PubMed  CAS  Google Scholar 

  97. Weisshart, K., Pestryakov, P., Smith, R. W., Hartmann, H., Kremmer, E., Lavrik, O., and Nasheuer, H.-P. (2004) J. Biol. Chem., 279, 35368–35376.

    Article  PubMed  CAS  Google Scholar 

  98. Lohman, T. M., and Bujalowski, W. (1994) Biochemistry, 33, 6167–6176.

    Article  PubMed  CAS  Google Scholar 

  99. Fanning, E., Klimovich, V., and Nager, A. R. (2006) Nucleic Acids Res., 34, 4126–4137.

    Article  PubMed  CAS  Google Scholar 

  100. Mass, G., Nethanel, T., and Kaufmann, G. (1998) Mol. Cell. Biol., 18, 6399–6407.

    PubMed  CAS  Google Scholar 

  101. Mass, G., Nethanel, T., Lavrik, O. I., Wold, M. S., and Kaufmann, G. (2001) Nucleic Acids Res., 29, 3892–3899.

    Article  PubMed  CAS  Google Scholar 

  102. Krasikova, Yu. S., Belousova, E. A., Lebedeva, N. A., Pestryakov, P. E., and Lavrik, O. I. (2008) Biochemistry (Moscow), accepted for publication.

  103. Maga, G., Shevelev, I., Villani, G., Spadari, S., and Hubscher, U. (2006) Nucleic Acids Res., 34, 1405–1415.

    Article  PubMed  CAS  Google Scholar 

  104. Maga, G., Villani, G., Crespan, E., Wimmer, U., Ferrari, E., Bertocci, B., and Hubscher, U. (2007) Nature, 447, 606–608.

    Article  PubMed  CAS  Google Scholar 

  105. Crespan, E., Hubscher, U., and Maga, G. (2007) Nucleic Acids Res., 35, 5173–5181.

    Article  PubMed  CAS  Google Scholar 

  106. Gillet, L., and Scharer, O. (2006) Chem. Rev., 106, 253–276.

    Article  PubMed  CAS  Google Scholar 

  107. Sugasawa, K., Ng, J. M., Masutani, C., Iwai, S., van der Spek, P. J., Eker, A. P., Hanaoka, F., Bootsma, D., and Hoeijmakers, J. H. (1998) Mol. Cell., 2, 223–232.

    Article  PubMed  CAS  Google Scholar 

  108. Volker, M., Mone, M. J., Karmakar, P., van Hoffen, A., Schul, W., Vermeulen, W., Hoeijmakers, J. H., van Driel, R., van Zeeland, A. A., and Mullenders, L. H. (2001) Mol. Cell., 8, 213–224.

    Article  PubMed  CAS  Google Scholar 

  109. Rechkunova, N. I., Maltseva, E. A., and Lavrik, O. I. (2008) Mol. Biol. (Moscow), 42, 24–31.

    CAS  Google Scholar 

  110. Patrick, S. M., and Turchi, J. J. (1999) J. Biol. Chem., 274, 14972–14978.

    Article  PubMed  CAS  Google Scholar 

  111. Missura, M., Buterin, T., Hindges, R., Hubscher, U., Kasparkova, J., Brabec, V., and Naegeli, H. (2001) EMBO J., 20, 3554–3564.

    Article  PubMed  CAS  Google Scholar 

  112. Reardon, J. T., and Sancar, A. (2002) Mol. Cell Biol., 22, 5938–5945.

    Article  PubMed  CAS  Google Scholar 

  113. Patrick, S. M., and Turchi, J. J. (1998) Biochemistry, 37, 8808–8815.

    Article  PubMed  CAS  Google Scholar 

  114. Shuck, S. C., Short, E. A., and Turchi, J. J. (2008) Cell Res., 18, 64–72.

    Article  PubMed  CAS  Google Scholar 

  115. Smith, J., Zou, H., and Rothstein, R. (2000) Biochimie, 82, 71–78.

    Article  PubMed  CAS  Google Scholar 

  116. Schramke, V., Luciano, P., Brevet, V., Guillot, S., Corda, Y., Longhese, M. P., Gilson, E., and Geli, V. (2004) Nat. Genet., 36, 46–54.

    Article  PubMed  CAS  Google Scholar 

  117. Cohen, S., Jacob, E., and Manor, H. (2004) Biochim. Biophys. Acta, 1679, 129–140.

    PubMed  CAS  Google Scholar 

  118. Salas, T. R., Petruseva, I., Lavrik, O., Bourdoncle, A., Mergny, J. L., Favre, A., and Saintome, C. (2006) Nucleic Acids Res., 34, 4857–4865.

    Article  PubMed  CAS  Google Scholar 

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  1. Institute of Chemical Biology and Fundamental Medicine, Siberian Branch of the Russian Academy of Sciences, pr. Akademika Lavrentieva 8, 630090, Novosibirsk, Russia

    P. E. Pestryakov & O. I. Lavrik

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  1. P. E. Pestryakov
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Original Russian Text © P. E. Pestryakov, O. I. Lavrik, 2008, published in Uspekhi Biologicheskoi Khimii, 2008, Vol. 48, pp. 65–104.

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Pestryakov, P.E., Lavrik, O.I. Mechanisms of single-stranded DNA-binding protein functioning in cellular DNA metabolism. Biochemistry Moscow 73, 1388–1404 (2008). https://doi.org/10.1134/S0006297908130026

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