Biochemistry (Moscow)

, 73:751

Mechanisms of angiogenesis

Authors

    • Institute of Carcinogenesis, Blokhin Cancer Research CenterRussian Academy of Medical Sciences
Review

DOI: 10.1134/S0006297908070031

Cite this article as:
Karamysheva, A.F. Biochemistry Moscow (2008) 73: 751. doi:10.1134/S0006297908070031

Abstract

Tissue activity of angiogenesis depends on the balance of many stimulating or inhibiting factors. The key signaling system that regulates proliferation and migration of endothelial cells forming the basis of any vessel are vascular endothelium growth factors (VEGF) and their receptors. The VEGF-dependent signaling system is necessary for formation of the embryonic vascular system. Neoangiogenesis during tumor growth is also associated with activation of this signaling system. The biological significance of the effect of such system on the cells depends on the content in tissue of various factors of the VEGF family and their receptors, while in the case of VEGFA it is defined by the ratio of different isoforms of this growth factor. A number of other signaling systems are also involved in regulation of the main steps of vessel formation. The signaling system D114/Notch regulates selection of endothelial cells for beginning of angiogenic expansion by endowing particular properties to endothelial cells leading in this process. An important step in vessel stabilization and maturation is vascular wall formation. Signaling system PDGFB/PDGFRß as well as angiopoietins Ang1, Ang2, and their receptor Tie2 are involved in recruiting mural cells (pericytes and smooth muscle cells). Identification of key molecules involved in the regulation of angiogenesis may provide new possibilities for development of drugs suitable for inhibition of angiogenesis or its stimulation in various pathologies.

Key words

angiogenesis vascular endothelium growth factors (VEGF) neuropilins PDGFB angiopoietins

Abbreviations

a.a.

amino acid residues

Ang

angiopoietins

EGF

epidermal growth factor

FGF

fibroblast growth factor

PDGF

platelet-derived growth factor

PlGF

placental growth factor

RTK

receptor tyrosine kinases

TGF

transforming growth factor

VEGF

vascular endothelium growth factor

VEGFR

vascular endothelium growth factor receptor

Copyright information

© MAIK Nauka 2008