Laser Physics

, Volume 18, Issue 4, pp 486–490

Digital holographic interference microscopy in the study of the 3D morphology and functionality of human blood erythrocytes

  • T. V. Tishko
  • V. P. Titar
  • D. N. Tishko
  • K. V. Nosov
Laser Methods in Chemistry, Biology, and Medicine

DOI: 10.1134/s11490-008-4024-0

Cite this article as:
Tishko, T.V., Titar, V.P., Tishko, D.N. et al. Laser Phys. (2008) 18: 486. doi:10.1134/s11490-008-4024-0

Abstract

A digital holographic interference microscope is used to experimentally study the 3D morphology of human blood erythrocytes. It is demonstrated that, in addition to hematological diseases, the diseases of various genesises and external factors serve as the reasons for the morphological modifications of blood erythrocytes. A 3D model of erythrocyte is proposed to quantitatively estimate the effect of morphological modifications of blood erythrocytes on their functionality with respect to the oxygen transfer. It is demonstrated that the observed morphological modifications of erythrocytes lead to a significant decrease in the blood oxygen capacity and can serve as a reason for hypoxia.

PACS numbers

42.30.Wb42.40.Kw

Copyright information

© MAIK Nauka 2008

Authors and Affiliations

  • T. V. Tishko
    • 1
  • V. P. Titar
    • 1
  • D. N. Tishko
    • 1
  • K. V. Nosov
    • 1
  1. 1.Laboratory of Holography, Faculty of Radio PhysicsKharkov National UniversityKharkovUkraine