Russian Journal of Genetics: Applied Research

, Volume 4, Issue 1, pp 15–18

The analysis of the survivorship curves in Drosophila melanogaster with D-GADD45 overexpression

  • E. N. Plyusnina
  • M. V. Shaposhnikov
  • E. N. Andreeva
  • A. A. Moskalev
  • L. V. Omelyanchuk
Article

DOI: 10.1134/S2079059714010080

Cite this article as:
Plyusnina, E.N., Shaposhnikov, M.V., Andreeva, E.N. et al. Russ J Genet Appl Res (2014) 4: 15. doi:10.1134/S2079059714010080
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Abstract

It is well known that GADD45 overexpression in the nervous system leads to the increased longevity in Drosophila. In this study, we performed an approximation of survivorship curves in Drosophila with GADD45 overexpression using the Gompertz distribution. We showed that the life span prolongation is caused by the alteration of R parameter, reflecting the mortality rate at the beginning of adult life, and not by the alteration of another Gompertz distribution parameter, α, reflecting the exponentially growing mortality rate. In addition, we analyzed the survivorship curves in the case of radiation hormesis (the phenomenon of life span extension under the exposure to low doses of radiation) and confirmed the regularity stated above. On the basis of this regularity, we concluded it promising to search for geroprotectors among the substances decreasing the R parameter, which is easier to assess than the full survivorship curve.

Keywords

longevityDNA repairGADD45overexpressionlow doses of ionizing radiationhormesisDrosophila melanogaster

Copyright information

© Pleiades Publishing, Ltd. 2014

Authors and Affiliations

  • E. N. Plyusnina
    • 1
    • 2
  • M. V. Shaposhnikov
    • 1
    • 2
  • E. N. Andreeva
    • 3
  • A. A. Moskalev
    • 1
    • 2
    • 4
  • L. V. Omelyanchuk
    • 3
  1. 1.Institute of Biology, Komi Scientific Center, Ural BranchRussian Academy of SciencesSyktyvkarRussia
  2. 2.Syktyvkar State UniversitySyktyvkarRussia
  3. 3.Institute of Molecular and Cell Biology, Siberian BranchRussian Academy of SciencesNovosibirskRussia
  4. 4.Moscow Institute of Physics and Technology (State University)MoscowRussia