Abstract
The study of enzymatic and protective properties of recombinant IgA1 protease in active and mutant form has shown that the active form of IgA1 protease exhibited species- and type-specificity for mouse and human immunoglobulins. A mutant form, lacking enzymatic activity, had protective properties against meningococcal infection, induced by meningococcus serogroup A, B and C; it protected mice from lethal infection by live virulent cultures of heterologous serogroups of meningococcus. The results obtained in this study suggest that IgA1 protease may be considered as a perspective preparation at the stages of development of a polyvalent vaccine for protection of human against meningococcal infections of various etiology.
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Original Russian Text © O.V. Kotel’nikova, A.P. Alliluev, E.Yu. Drozhzhina, I.S. Koroleva, E.A. Sitnikova, A.A. Zinchenko, E.A. Gordeeva, T.D. Melikhova, E.A. Nokel, L.S. Zhigis, V.S. Zueva, O.A. Razgulyaeva, O.V. Serova, E.Yu. Yagudaeva, L.D. Rumsh, 2013, published in Biomeditsinskaya Khimiya.
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Kotel’nikova, O.V., Alliluev, A.P., Drozhzhina, E.Y. et al. Protective properties of recombinant IgA1 protease from meningococcus. Biochem. Moscow Suppl. Ser. B 7, 305–310 (2013). https://doi.org/10.1134/S1990750813040033
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DOI: https://doi.org/10.1134/S1990750813040033