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Multiple sclerosis and oxidative stress—a clinical perspective

  • Clinical Neurochemistry
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Abstract

Multiple Sclerosis (MS) has been traditionally considered to be a chronic inflammatory disease of central nervous system (CNS), resulting in demyelization and clinical presentation of physical disability. Such understanding of MS was solely related to neuroinflammation and its harmful effects; however, count-less data suggest the importance of neurodegenerative mechanisms that are evident in chronic demyelization plaques, and believed to be initiated by oxidative stress. CNS is particularly sensitive to oxidative attack due to the high level of oxygen utilization, relatively small amounts of conventional antioxidants and antioxidative enzymes, and large amounts of polyunsaturated lipids, biomolecules highly susceptible to oxidation. The role and significance of reactive oxygen species (ROS) in MS development has not been fully understood yet, it is believed that ROS formation is primarily orchestrated by immunoinflammatory mechanisms, but there are also data suggesting that certain inflammation independent mechanisms can result in neuronal degeneration and demyelization. They are mainly related to abnormal mitochondria functioning, glutamate excitotoxicity and the disruption of redox active metal homeostasis. Today, there is still a debate whether MS is an immunoinflammatory or neurodegenerative disorder; is it a cause or a consequence of oxidative stress, although clinical trials show encouraging results of antioxidant therapy usage in the disease management.

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References

  1. Manji, H., Connolly, S., Dorward, N., Kitchen, N., Mehta, A., and Wills, A., Oxford Handbook of Neurology, New York: Oxford University Press, 2009.

    Google Scholar 

  2. Miller, E., Mrowicka, M., Zolyinski, K., and Kedziora, J., Pol Merkur. Lekarski., 2009, vol. 27, no. 162, pp. 499–502.

    PubMed  CAS  Google Scholar 

  3. Sayre, L.M., Perry, G., and Smith, M.A., Chem. Res. Toxicol., 2008, vol. 21, no. 1, pp. 172–188.

    Article  PubMed  Google Scholar 

  4. Mirshafiey, A. and Mohsenzadegan, M., Journal of Chinese Clinical Medicine, 2008, vol. 3, no. 7, pp. 405–411.

    CAS  Google Scholar 

  5. Kirkinezos, I.G. and Moraes, C.T., Semin. Cell Dev. Biol., 2001, vol. 12, no. 6, pp. 449–457.

    Article  PubMed  CAS  Google Scholar 

  6. Ischiropoulos, H. and Beckman, J.S., J. Clin. Invest., 2003, vol. 111, no. 2, pp. 163–169.

    PubMed  CAS  Google Scholar 

  7. Liu, J.S., Zhao, M.L., Brosnan, C.F., and Lee, S.C., Am. J. Pathol., 2001, vol. 158, no. 6, pp. 2057–2066.

    Article  PubMed  CAS  Google Scholar 

  8. Syburra, C. and Passi, S., Ukr. Biokhim. Zh., 1999, vol. 71, no. 3, pp. 112–115.

    PubMed  CAS  Google Scholar 

  9. Miller, E., Walczak, A., Saluk, J., Ponczek, M.B., and Majsterek, I., Clin. Biochem., 2012, vol. 45, nos. 1–2, pp. 26–30.

    Article  PubMed  CAS  Google Scholar 

  10. Giovannoni, G., Heales, S.J., Silver, N.C., O’Riordan, J., Miller, R.F., Land, J.M., Clark, J.B., and Thompson, E.J., J. Neurol. Sci., 1997, vol. 145, no. 1, pp. 77–81.

    Article  PubMed  CAS  Google Scholar 

  11. Giovannoni, G., Mult. Scler., 1998, vol. 4, no. 1, pp. 27–30.

    Article  PubMed  CAS  Google Scholar 

  12. Drulovic, J., Dujmovic, I., Mesaros, S., Samardzic, T., Maksimovic, D., Stojsavljevic, N., Levic, Z., and Mostarica-Stojokvic, M., Mult. Scler., 2001, vol. 7, no. 1, pp. 19–22.

    Article  PubMed  CAS  Google Scholar 

  13. Greco, A., Minghetti, L., Sette, G., Fieschi, C., and Levi, G., Neurology, 1999, vol. 53, no. 8, pp. 1876–1879.

    Article  PubMed  CAS  Google Scholar 

  14. Greco, A., Minghetti, L., and Levi, G., Neurochem. Res., 2000, vol. 25, nos. 9–10, pp. 1357–1364.

    Article  PubMed  CAS  Google Scholar 

  15. Ghabaee, M., Jabedari, B., Al-E-Eshagh, N., Ghaffarpour, M., and Asadi, F., Int. J. Neurosci., 2010, vol. 120, no. 4, pp. 301–304.

    Article  PubMed  CAS  Google Scholar 

  16. Haider, L., Fischer, M.T., Frischer, J.M., Bauer, J., Höftberger, R., Botond, G., Esterbauer, H., Binder, C.J., Witztum, J.L., and Lassmann, H., Brain, 22011, vol. 134, no. 7, pp. 1914–1924.

    Article  PubMed  Google Scholar 

  17. Liu, B. and Hong, J.S., J. Pharmacol. Exp. Ther., 2003, vol. 304, no. 1, pp. 1–7.

    Article  PubMed  CAS  Google Scholar 

  18. Mao, P. and Reddy, H.P., Biochim. Biophys. Acta, 2010, vol. 1802, no. 1, pp. 66–79.

    Article  PubMed  CAS  Google Scholar 

  19. Stover, J.F., Pleines, U.E., Morganti-Kossmann, M.C., Kossmann, T., Lowitzsch, K., and Kempski, O.S., Eur. J. Clin. Invest., 1997, vol. 27, no. 12, pp. 1038–1043.

    Article  PubMed  CAS  Google Scholar 

  20. LeVine, S.M. and Chakrabarty, A., Ann. N. Y. Acad. Sci., 2004, vol. 1012, pp. 252–266.

    Article  PubMed  CAS  Google Scholar 

  21. Lohr, J., Knoechel, B., Caretto, D., and Abbas, A.K., Microbes. Infect., 2009, vol. 11, no. 5, pp. 589–593.

    Article  PubMed  CAS  Google Scholar 

  22. Romagnani, S., Maggi, E., Liotta, F., Cosmi, L., and Annunziato, F., Mol. Immunol., 2009, vol. 47, no. 1, pp. 3–7.

    Article  PubMed  CAS  Google Scholar 

  23. Matsui, M., Neurology Asia, 2008, vol. 13, pp. 195–198.

    Google Scholar 

  24. Kasper, L.H. and Shoemaker, J., Neurology, 2010, vol. 74,Suppl. 1, pp. S2–8.

    Article  PubMed  CAS  Google Scholar 

  25. Schidt-Glenewinkel, T. and Figueiredo-Pereira, M., Proteasome in Neurodegeneration, New York: Springer science + business media, INC, 2006, pp. 105–131.

    Book  Google Scholar 

  26. Consilvio, C., Vincent, A.M., and Feldman, E.L., Exp. Neurol., 2004, vol. 187, no. 1, pp. 1–10.

    Article  PubMed  CAS  Google Scholar 

  27. Kondo, M., Oya-Ito, T., Kumagai, T., Osawa, T., and Uchida, K., J. Biol. Chem., 2001, vol. 276, no. 15, pp. 12076–12083.

    Article  PubMed  CAS  Google Scholar 

  28. Rock, B.R., Gekker, G., Hu, S., Sheng, W.S., Cheeran, M., Lokensgard, J.R., and Peterson, P.K., Clin. Microbiol. Rev., 2004, vol. 17, no. 4, pp. 942–964.

    Article  PubMed  CAS  Google Scholar 

  29. Maccarrone, M., Melino, G., and Finazzi-Agro, A., Cell. Death. Differ., 2001, vol. 8, no. 8, pp. 776–784.

    Article  PubMed  CAS  Google Scholar 

  30. Hoffmann, G., Wirleitner, B., and Fuchs, D., Inflamm. Res., 2003, vol. 52, no. 8, pp. 313–321.

    Article  PubMed  CAS  Google Scholar 

  31. Dhib-Jalbut, S., Arnold, D.L., Cleveland, D.W., Fisher, M., Friediander, R.M., and Mouradian, M.M., J. Immunol., 2006, vol. 176, nos. 1–2, pp. 198–215.

    CAS  Google Scholar 

  32. Wilkinson, B.L. and Landreth, G.E., J. Neuroinflammation, 2006, vol. 30, no. 3.

    Google Scholar 

  33. Louten, J., Boniface, K., and de Waal Malefyt, R., J. Allergy. Clin. Immunol., 2009, vol. 123, no. 5, pp. 1004–1011.

    Article  PubMed  CAS  Google Scholar 

  34. Shen, F. and Gaffen, S.L., Cytokine, 2008, vol. 41, no. 2, pp. 92–104.

    Article  PubMed  CAS  Google Scholar 

  35. Pietrowski, E., Bender, B., Huppert. J., White, R., Luhmann, H.J., and Kuhlmann, C.R.W., J. Vase. Res., 2010, vol. 48, no. 1, pp. 52–58.

    Article  Google Scholar 

  36. Huppert, J., Closhen, D., Croxford, D., White, R., Kulig, P., Pietrowski, E., Bechmann, I., Becher, B., Luhmann, H.J., Waisman, A., and Kuhlmann C.R., FASEB J., 2009, vol. 24, no. 4, pp. 1023–1034.

    Article  PubMed  Google Scholar 

  37. Mahad, D., Lassmann, H., and Turnbull, D., Neuropathol. Appl. Neurobiol., 2008, vol. 34, no. 6, pp. 577–589.

    Article  PubMed  CAS  Google Scholar 

  38. Vogler, S., Goedde, R., Miterski, B., Gold, R., Kroner, A., Koczan, D., Zettl, U.K., Rieckmann, P., Epplen, J.T., and Ibrahim, S.M., J. Mol. Med., 2005, vol. 83, no. 10, pp. 806–811.

    Article  PubMed  CAS  Google Scholar 

  39. Vyshkina, T., Banisor, L, Shugart, Y.Y., Leist, T.P., and Kalman, B., J. Neurol. Sci., 2005, vol. 228, no. 1, pp. 55–64.

    Article  PubMed  CAS  Google Scholar 

  40. Lucchinetti, C., Bruck, W., Parisi, J., Scheithauer, B., Rodriguez, M., and Lassmann, H., Ann. Neurol., 2000, vol. 47, no. 6, pp. 707–717.

    Article  PubMed  CAS  Google Scholar 

  41. Lu, F., Selak, M., O’Connor, J., Croul, S., Lorenzana, C., and Butunoi, C., J. Neurol. Sci., 2000, vol. 177, no. 2, pp. 95–103.

    Article  PubMed  CAS  Google Scholar 

  42. Croteau, D.L., Stierum, H., and Bohr, V.A., Mutat. Res., 1999, vol. 434, no. 3, pp. 137–148.

    Article  PubMed  CAS  Google Scholar 

  43. Druzhyna, N.M., Musiyenko, S.I., Wilson, G.L., and LeDoux, S.P., J. Biol. Chem., 2005, vol. 280, no. 22, pp. 21673–21679.

    Article  PubMed  CAS  Google Scholar 

  44. Baines, C.P., Kaiser, R.A., Purcell, N.H., Blair, N.S., Osinska, H., Hambleton, M.A., Brunskill, E.W., Sayen, M.R., Gottlieb, R.A., Dorn, G.W., Robbins, J., and Molkentin, J.D., Nature, 2005, vol. 434, no. 7033, pp. 658–662.

    Article  PubMed  CAS  Google Scholar 

  45. Forte, M., Gold, B.G., Marracci, G., Chaudhary, P., Basso, E., Johnsen, D., Yu, X., Fowlkes, J., Rahder, M., Stem, K., Bernardi, P., and Bourdette, D., Proc. Natl. Acad. Sci. USA, 2007, vol. 104, no. 18, pp. 7558–7563.

    Article  PubMed  CAS  Google Scholar 

  46. Gonsette, R.E., J. Neurol Sci., 2008, vol. 274, nos. 1–2, pp. 48–53.

    Article  PubMed  CAS  Google Scholar 

  47. Mark, L.P., Prost, R.W., Ulmer, J.L., Smith, M.M., Daniels, D.L., Strottmann, J.M., Brown, W.D., and Hacein-Bey, L., AJNR Am. J. Neuroradiol., 2001, vol. 22, no. 10, pp. 1813–1824.

    PubMed  CAS  Google Scholar 

  48. Hardin-Pouzet, H., Krakowski, M., Bourbonnière, L., Didier-Bazes, M., Tran, E., and Owens, T., Glia, 1997, vol. 20, no. 1, pp. 79–85.

    Article  PubMed  CAS  Google Scholar 

  49. Trotti, D., Rossi, D., Gjesdal, O., Levy, L.M., Racagni, G., Danbolt, N.C., and Volterra, A., J. Biol. Chem., 1996, vol. 271, no. 11, pp. 5976–5979.

    Article  PubMed  CAS  Google Scholar 

  50. Pitt, D., Werner, P., and Raine, C.S., Nat. Med., 2000, vol. 6, no. 1, pp. 6770.

    Google Scholar 

  51. Singh, A.V. and Zamboni, P., J. Cereb. Blood Flow Metab., 2009, vol. 29, no. 12, pp. 1867–1878.

    Article  PubMed  CAS  Google Scholar 

  52. Mehindate, K., Sahlas, D.J., Frankel, D., Mawal, Y., Liberman, A., Corcos, J., Dion, S., and Schopper, H.M., J. Neurochem., 2001, vol. 77, no. 5, pp. 1386–1395.

    Article  PubMed  CAS  Google Scholar 

  53. Schipper, H.M., Bernier, L., Mehindate, K., and Frankel, T.D., J. Neurochem., 1999, vol. 72, no. 5, pp. 1802–1811.

    Article  PubMed  CAS  Google Scholar 

  54. Schipper, H.M., Song, W., Zukor, H., Haskalovici, J.R., and Zeligman, D., J. Neurochem., 2009, vol. 110, no. 2, pp. 469–485.

    Article  PubMed  CAS  Google Scholar 

  55. Emerson, M.R. and LeVine, S.M., J. Neurochem., 2000, vol. 75, no. 6, pp. 2555–2562.

    Article  PubMed  CAS  Google Scholar 

  56. Simka, M., Kostecki, J., Zaniewski, M., Majewski, E., and Hartel, M., Int. Angiol., 2010, vol. 29, no. 2, pp. 109–114.

    PubMed  CAS  Google Scholar 

  57. Al-Omari, M.H. and Rousan, L.A., Int. Angiol., 2010, vol. 29, no. 2, pp. 115–120.

    PubMed  CAS  Google Scholar 

  58. Sundstrom, P., Wahlin, A., Ambarki, K., Birgander, R., Eklund, A., and Malm, J., Ann. Neurol., 2010, vol. 68, no. 2, pp. 255–259.

    Article  PubMed  Google Scholar 

  59. Zivadinov, R., Galeotti, R., Hojnacki, D., Menegatti, E., Dwyer, M.G., Schirda, C., Malagoni, A.M., Marr, K., Kennedy, C., Bartolomei, I., Magnano, C., Salvi, F., Weinstock-Guttman, B., and Zamboni, P., AJNR Am. J. Neuroradiol., 2011, vol. 32, no. 5, pp. 938–946.

    Article  PubMed  CAS  Google Scholar 

  60. D’haeseleer, M., Cambron, M., Vanopdenbosch, L., and De Keyser, J., Lancet Neurol., 2011, vol. 10, no. 7, pp. 657–666.

    Article  PubMed  Google Scholar 

  61. Gilgun-Sherki, Y., Melamed, E., and Offen, D., J. Neurol., 2004, vol. 251, no. 3, pp. 261–268.

    Article  PubMed  CAS  Google Scholar 

  62. Scott, G.S., Spitsin, S.V., Kean, R.B., Mikheeva, T., Koprowski, H., and Hooper, D.C., Proc. Natl. Acad. Sci. USA, 2002, vol. 99, no. 25, pp. 16303–16308.

    Article  PubMed  CAS  Google Scholar 

  63. Spitsin, S., Hooper, D.C., Leist, T., Streletz, L.J., Mikheeva, T., and Koprowski, H., Mult. Scler., 2001, vol. 7, no. 5, pp. 313–319.

    PubMed  CAS  Google Scholar 

  64. Markowitz, C.E., Spitsin, S., Zimmerman, V., Jacobs, D., Udupa, J.K., Hooper, D.C., and Koprowski, H., J. Altern. Complement. Med., 2009, vol. 15, no. 6, pp. 619–625.

    Article  PubMed  Google Scholar 

  65. Gonsette, R.E., Sindic, C., D’hooghe, M.B., De Deyn, P.P., Medaer, R., Michotte, A., Seeldrayers, P., and Guillaume, D., Mult. Scler., 2010, vol. 16, no. 4, pp. 455–462.

    Article  PubMed  CAS  Google Scholar 

  66. Stanislaus, R., Gilg, A.G., Singh, A.K., and Singh, I., J. Autoimmune. Dis., 2005, vol. 2, no. 1, pp. 4.

    Article  PubMed  Google Scholar 

  67. Ates, B., Abraham, L., and Ercal, N., Free Radio. Res., 2008, vol. 42, no. 4, pp. 372–377.

    Article  CAS  Google Scholar 

  68. Gilgun-Sherki, Y., Barhum, Y., Atlas, D., Melamed, E., and Offen, D., J. Mol. Neurosci., 2005, vol. 27, no. 1, pp. 125–135.

    Article  PubMed  CAS  Google Scholar 

  69. Mohamed, A., Afridi, D.M., Garani, O., and Tucci, M., Biomed. Sci. Instrum., 2005, vol. 41, pp. 388–393.

    PubMed  CAS  Google Scholar 

  70. Liu, Y., Zhu, B., Wang, X., Luo, L., Li, P., and Paty, D.W., J. Neuroimmunol., 2003, vol. 139, no. 1, pp. 27–35.

    Article  PubMed  CAS  Google Scholar 

  71. Liu, Y., Li, P., Lu, J., Xiong, W., Oger, J., Tetzlaff, W., and Cynader, M., J. Immunol., 2008, vol. 181, no. 3, pp. 1887–1897.

    PubMed  CAS  Google Scholar 

  72. Peng, F., Deng, X., Yu, Y., Chen, X., Shen, L., Zhong, X., Qiu, W., Jiang, Y., Zhang, J., and Hu, X., Clin. Neurosci., 2011, vol. 18, no. 10, pp. 1355–1359.

    Article  CAS  Google Scholar 

  73. Lobejko, K., Mitrosek-Szewczyk, K., Kurzepa, J., Berbecki, J., and Stelmasiak, Z., Annales Universitatis Mariae Curie, 2010, vol. 23, no. 1, pp. 137–142.

    Google Scholar 

  74. Schreibelt, G., Van Horssen, J., Van Rossum, S., Dijkstra, C.D., Drukarch, B., and De Vries, H.E., Brain Res. Rev., 2007, vol. 56, no. 2, pp. 322–330.

    Article  PubMed  CAS  Google Scholar 

  75. Bernstein, A.I. and Miller, G.W., Toxicol. Sci., 2010, vol. 114, no. 2, pp. 159–161.

    Article  PubMed  CAS  Google Scholar 

  76. Van Horssen, J., Drexhage, J.A., Flor, T., Gerritsen, W., van der Valk, P., and de Vries, H.E., Free Radic. Biol. Med., 2010, vol. 49, no. 8, pp. 1283–1289.

    Article  PubMed  Google Scholar 

  77. Nguyen, T., Nioi, P., and Pickett, C.B., J. Biol. Chem., 2009, vol. 284, no. 20, pp. 13291–13295.

    Article  PubMed  CAS  Google Scholar 

  78. Schilling, S., Goelz, S., Linker, R., Luehder, F., and Gold, R., Clin. Exp. Immunol., 2006, vol. 145, no. 1, pp. 101–107.

    Article  PubMed  CAS  Google Scholar 

  79. Wilms, H., Sievers, J., Rickert, U., Rostami-Yazdi, M., Mrowietz, U., and Lucius, R., J. Neuroinflammation., 2010, vol. 7, pp. 30.

    Article  PubMed  Google Scholar 

  80. Lukashev, M., Zeng, W., Ryan, S., Dawson, K., O’Neill, G.N., Goelz, S.E., Lee, D.H., Linker, R., Drukarch, B., Van Dam, A.M., and Gold, R., Neurology, 2008, vol. 70,Suppl. 1, p. A27.

    Google Scholar 

  81. Kappos, L., Miller, D., MacManus, D., Gold, R., Havrdova, E., Limmroth, V., Polman, C, Schmierer, K., Yousry, T., Yang, M., Erakosy, M., Meluzinova, E., Rektor, I., and O’Neill, G., Lancet, 2008, vol. 372, no. 9648, pp. 1463–1472.

    Article  PubMed  CAS  Google Scholar 

  82. Liu, B., Du, L., and Hong, J.S., J. Phar. Exp. Ther., 2000, vol. 293, no. 2, pp. 607–617.

    CAS  Google Scholar 

  83. Liu, B., Jiang, J.W., Wilson, B., Du, L., Yang, S.N., and Wang, J.Y., J. Pharmacol. Exp. Ther., 2000, vol. 295, no. 1, pp. 125–132.

    PubMed  CAS  Google Scholar 

  84. Wang, Y., Perchellet, E.M., Ward, M.M., Lou, K, Hua, D.H., and Percheilet, J.P., Anticancer Drugs, 2005, vol. 16, no. 9, pp. 953–967.

    Article  PubMed  CAS  Google Scholar 

  85. Mao, P., Ardeshiri, A., Jacks, R., Yang, S., Hum, P.D., and Alkayed, N.J., Eur. J. Neurosci., 2007, vol. 26, no. 3, pp. 24–32.

    Article  CAS  Google Scholar 

  86. Smith, T., Groom, A., Zhu, B., and Turski, L., NatMed., 2000, vol. 6, no. 1, pp. 62–66.

    Article  CAS  Google Scholar 

  87. G. Bensimon, G., Lamcoblez, L., and Meninger, V., New Engl. J. Med., 1994, vol. 330, no. 9, pp. 585–591.

    Article  PubMed  CAS  Google Scholar 

  88. Gilgun-Sherki, Y., Panet, H., Melamed, E., and Offen, D., Brain Res., 2003, vol. 989, no. 2, pp. 196–204.

    Article  PubMed  CAS  Google Scholar 

  89. Killestein, J., Kalkers, N.F., and Polman, C.H., J. Neurol. Sci., 2005, vol. 233, nos. 1–2, pp. 113–115.

    Article  PubMed  CAS  Google Scholar 

  90. Black, J.A., Liu, S., Hains, B.C., Saab, C.Y., and Waxman, S.G., Brain, 2006, vol. 129, no. 12, pp. 3196–3208.

    Article  PubMed  Google Scholar 

  91. Lo, A.C., Saab, C.Y., Black, J.A., and Waxman, S.G., J. Neurophysiol., 2003, vol. 90, no. 5, pp. 3566–3571.

    Article  PubMed  CAS  Google Scholar 

  92. Zamboni, P., Galeotti, R., Menegatti, E., Malagoni, A.M., Gianesini, S., Bartolomei, I., Mascoli, F., and Salvi, F., J. Vasc. Surg., 2009, vol. 50, no. 6, pp. 1348–1358.

    Article  PubMed  Google Scholar 

  93. Reekers, J.A., Lee, M.J., Belli, A.M. and Barkhof, F., Cardiovasc. Intervent. Radiol., 2011, vol. 34, no. 1, pp. 1–2.

    Article  PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Immunology, Faculty of Medicine, University of Nis, Nis, Serbia

    M. S. Kostic & I. D. Dimov

  2. Department of Immunology, Faculty of Natural Sciences and Mathematics, University of Nis, Nis, Serbia

    J. S. Rajkovic

  3. Institute for Biomedical Research, Faculty of Medicine, University of Nis, Nis, Serbia

    M. S. Potic Floranovic

  4. Department of Biochemistry, Faculty of Medicine, University of Nis, Nis, Serbia

    D. D. Pavlovic

  5. bul. Zorana Djindjica 81, Nis, 18000, Serbia

    M. S. Kostic

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Kostic, M.S., Rajkovic, J.S., Floranovic, M.S.P. et al. Multiple sclerosis and oxidative stress—a clinical perspective. Neurochem. J. 7, 76–86 (2013). https://doi.org/10.1134/S1819712412040083

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