Characteristics of oxidative stress in experimental rat brain ischemia aggravated by homocysteic acid
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- Dobrotvorskaya, I.S., Fedorova, T.N., Dobrota, D. et al. Neurochem. J. (2011) 5: 42. doi:10.1134/S1819712410041014
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We developed a new experimental model of oxidative stress in rats, which combines the effects of 3-vessel brain ischemia and an increased level of homocysteine in blood circulation. We compared the protective effects of two compounds, the agonist of cannabinoid receptors Win5521-2 and the natural antioxidant carnosine. We found that Win5521-2 has a protective effect only at a normal blood level of homocysteine, whereas carnosine is also effective under conditions of elevated homocysteine level.