, Volume 5, Issue 1, pp 42-46
Date: 24 Mar 2011

Characteristics of oxidative stress in experimental rat brain ischemia aggravated by homocysteic acid

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Abstract

We developed a new experimental model of oxidative stress in rats, which combines the effects of 3-vessel brain ischemia and an increased level of homocysteine in blood circulation. We compared the protective effects of two compounds, the agonist of cannabinoid receptors Win5521-2 and the natural antioxidant carnosine. We found that Win5521-2 has a protective effect only at a normal blood level of homocysteine, whereas carnosine is also effective under conditions of elevated homocysteine level.

Original Russian Text © I.S. Dobrotvorskaya, T.N. Fedorova, D. Dobrota, T.T. Berezov, 2011, published in Neirokhimiya, 2011, Vol. 28, No. 1, pp. 49–54.