Neurochemical Journal

, 5:42

Characteristics of oxidative stress in experimental rat brain ischemia aggravated by homocysteic acid

  • I. S. Dobrotvorskaya
  • T. N. Fedorova
  • D. Dobrota
  • T. T. Berezov
Experimental Articles

DOI: 10.1134/S1819712410041014

Cite this article as:
Dobrotvorskaya, I.S., Fedorova, T.N., Dobrota, D. et al. Neurochem. J. (2011) 5: 42. doi:10.1134/S1819712410041014

Abstract

We developed a new experimental model of oxidative stress in rats, which combines the effects of 3-vessel brain ischemia and an increased level of homocysteine in blood circulation. We compared the protective effects of two compounds, the agonist of cannabinoid receptors Win5521-2 and the natural antioxidant carnosine. We found that Win5521-2 has a protective effect only at a normal blood level of homocysteine, whereas carnosine is also effective under conditions of elevated homocysteine level.

Keywords

global brain ischemia homocysteine oxidative stress carnosine Win5521-2 

Copyright information

© Pleiades Publishing, Ltd. 2011

Authors and Affiliations

  • I. S. Dobrotvorskaya
    • 1
    • 2
  • T. N. Fedorova
    • 2
  • D. Dobrota
    • 3
  • T. T. Berezov
    • 1
  1. 1.Laboratory of Biochemistry of Amines and Cyclic Nucleotides, Institute of Biomedical ChemistryRussian Academy of Medical SciencesMoscowRussia
  2. 2.Laboratory of Clinical and Experimental Neurochemistry, Research Centre of NeurologyRussian Academy of Medical SciencesMoscowRussia
  3. 3.Department of Medical Biochemistry, Jesseinus Faculty of MedicineComenius UniversityMartinSlovak Republic
  4. 4.MoscowRussia