Effect of homocysteine on respiratory burst in neutrophils induced by chemotaxis factor fMLP
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- Vladychenskaya, E.A. & Boldyrev, A.A. Neurochem. J. (2009) 3: 64. doi:10.1134/S1819712409010103
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Homocysteine is a risk factor of many neurodegenerative and cardiovascular diseases. The target for its effect was suggested to be brain neurons. Recently, it was found that homocysteine can affect immune competent cells. In this work we have shown that, in neutrophils, homocysteine stimulates the amplitude and initial rate of respiratory burst induced by fMLP. Adenosine receptors of the A1 and A2 types are involved in this process but not the A3 type. Phospholipase C is also involved in the stimulation of the fMLP-induced respiratory burst by homocysteine.