Radiochemistry

, Volume 49, Issue 6, pp 630–632

Nuclear-chemical synthesis of tritium-labeled phenyl-substituted picoline derivatives

  • N. E. Shchepina
  • V. V. Avrorin
  • G. A. Badun
  • V. M. Fedoseev
  • S. E. Ukhanov
  • S. B. Lewis
Article

DOI: 10.1134/S1066362207060161

Cite this article as:
Shchepina, N.E., Avrorin, V.V., Badun, G.A. et al. Radiochemistry (2007) 49: 630. doi:10.1134/S1066362207060161
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Abstract

Ion-molecule reactions of free phenyl cations with six-membered nitrogen-containing heterocyclic compounds: α-, β-, and γ-picolines, were studied. Phenyl cations were generated by tritium β-decay in double-labeled benzene. The mechanism of competing reactions of electrophilic addition to the nitrogen heteroatom in the ring and electrophilic substitution of the C-H bond in the pyridine ring was examined. The effect of methyl substituent in the pyridine molecule on the reaction pathway was evaluated. A one-step procedure for nuclear-chemical synthesis of tritium-labeled N-phenylpicolinium salts and phenyl-substituted picolines was developed.

PACS numbers

82.30.Fi 

Copyright information

© Pleiades Publishing, Inc. 2007

Authors and Affiliations

  • N. E. Shchepina
    • 1
  • V. V. Avrorin
    • 2
  • G. A. Badun
    • 3
  • V. M. Fedoseev
    • 3
  • S. E. Ukhanov
    • 4
  • S. B. Lewis
    • 5
  1. 1.Natural Science InstitutePermRussia
  2. 2.St. Petersburg State UniversitySt. PetersburgRussia
  3. 3.Lomonosov Moscow State UniversityMoscowRussia
  4. 4.Perm Technical UniversityPermRussia
  5. 5.James Madison UniversityHarrisonburgUSA

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