Nuclear-chemical synthesis of tritium-labeled phenyl-substituted picoline derivatives
- Cite this article as:
- Shchepina, N.E., Avrorin, V.V., Badun, G.A. et al. Radiochemistry (2007) 49: 630. doi:10.1134/S1066362207060161
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Ion-molecule reactions of free phenyl cations with six-membered nitrogen-containing heterocyclic compounds: α-, β-, and γ-picolines, were studied. Phenyl cations were generated by tritium β-decay in double-labeled benzene. The mechanism of competing reactions of electrophilic addition to the nitrogen heteroatom in the ring and electrophilic substitution of the C-H bond in the pyridine ring was examined. The effect of methyl substituent in the pyridine molecule on the reaction pathway was evaluated. A one-step procedure for nuclear-chemical synthesis of tritium-labeled N-phenylpicolinium salts and phenyl-substituted picolines was developed.