, Volume 63, Issue 6, pp 516-529
Date: 31 May 2008

High-performance liquid chromatography in the analysis of multicomponent pharmaceutical preparations

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Abstract

A review of publications for the last 10–12 years on the HPLC analysis of multicomponent pharmaceutical formulations is presented. The peculiarities of the analysis of drug products are discussed, including applied adsorbents, mobile-phase composition, elution mode, derivatization procedure, detectors, and methods for reducing the time of analysis. The use of ion-exchange, ion-pair, and enantioselective HPLC in determining the components of pharmaceutical preparations is considered.

Original Russian Text © A.V. Kostarnoi, G.B. Golubitskii, E.M. Basova, E.V. Budko, V.M. Ivanov, 2008, published in Zhurnal Analiticheskoi Khimii, 2008, Vol. 63, No. 6, pp. 566–580.