Journal of Analytical Chemistry

, Volume 63, Issue 6, pp 516–529

High-performance liquid chromatography in the analysis of multicomponent pharmaceutical preparations


  • A. V. Kostarnoi
    • OAO Pharmstandard-Leksredstva
  • G. B. Golubitskii
    • OAO Pharmstandard-Leksredstva
  • E. M. Basova
    • Dubna International University of Nature, Society, and Human Being
  • E. V. Budko
    • Kursk State Medical University
  • V. M. Ivanov
    • Department of ChemistryMoscow State University

DOI: 10.1134/S1061934808060026

Cite this article as:
Kostarnoi, A.V., Golubitskii, G.B., Basova, E.M. et al. J Anal Chem (2008) 63: 516. doi:10.1134/S1061934808060026


A review of publications for the last 10–12 years on the HPLC analysis of multicomponent pharmaceutical formulations is presented. The peculiarities of the analysis of drug products are discussed, including applied adsorbents, mobile-phase composition, elution mode, derivatization procedure, detectors, and methods for reducing the time of analysis. The use of ion-exchange, ion-pair, and enantioselective HPLC in determining the components of pharmaceutical preparations is considered.

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© MAIK Nauka 2008