Journal of Analytical Chemistry

, Volume 63, Issue 6, pp 516–529

High-performance liquid chromatography in the analysis of multicomponent pharmaceutical preparations

  • A. V. Kostarnoi
  • G. B. Golubitskii
  • E. M. Basova
  • E. V. Budko
  • V. M. Ivanov
Reviews

DOI: 10.1134/S1061934808060026

Cite this article as:
Kostarnoi, A.V., Golubitskii, G.B., Basova, E.M. et al. J Anal Chem (2008) 63: 516. doi:10.1134/S1061934808060026

Abstract

A review of publications for the last 10–12 years on the HPLC analysis of multicomponent pharmaceutical formulations is presented. The peculiarities of the analysis of drug products are discussed, including applied adsorbents, mobile-phase composition, elution mode, derivatization procedure, detectors, and methods for reducing the time of analysis. The use of ion-exchange, ion-pair, and enantioselective HPLC in determining the components of pharmaceutical preparations is considered.

Copyright information

© MAIK Nauka 2008

Authors and Affiliations

  • A. V. Kostarnoi
    • 1
  • G. B. Golubitskii
    • 1
  • E. M. Basova
    • 2
  • E. V. Budko
    • 3
  • V. M. Ivanov
    • 4
  1. 1.OAO Pharmstandard-LeksredstvaKurskRussia
  2. 2.Dubna International University of Nature, Society, and Human BeingDubna, Moscow oblastRussia
  3. 3.Kursk State Medical UniversityKurskRussia
  4. 4.Department of ChemistryMoscow State UniversityLeninskie gory, MoscowRussia