Journal of Analytical Chemistry

, Volume 63, Issue 6, pp 516-529

First online:

High-performance liquid chromatography in the analysis of multicomponent pharmaceutical preparations

  • A. V. KostarnoiAffiliated withOAO Pharmstandard-Leksredstva
  • , G. B. GolubitskiiAffiliated withOAO Pharmstandard-Leksredstva
  • , E. M. BasovaAffiliated withDubna International University of Nature, Society, and Human Being
  • , E. V. BudkoAffiliated withKursk State Medical University
  • , V. M. IvanovAffiliated withDepartment of Chemistry, Moscow State University

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A review of publications for the last 10–12 years on the HPLC analysis of multicomponent pharmaceutical formulations is presented. The peculiarities of the analysis of drug products are discussed, including applied adsorbents, mobile-phase composition, elution mode, derivatization procedure, detectors, and methods for reducing the time of analysis. The use of ion-exchange, ion-pair, and enantioselective HPLC in determining the components of pharmaceutical preparations is considered.