Journal of Analytical Chemistry

, Volume 61, Issue 11, pp 1108–1112

Dynamic coating of a capillary with room-temperature ionic liquids for the separation of amino acids and acid drugs by capillary electrophoresis

  • T. -F. Jiang
  • Y. -H. Wang
  • Z. -H. Lv
Articles

DOI: 10.1134/S1061934806110128

Cite this article as:
Jiang, T.F., Wang, Y.H. & Lv, Z.H. J Anal Chem (2006) 61: 1108. doi:10.1134/S1061934806110128

Abstract

A room-temperature ionic liquid (IL), 1-ethyl-3-methyl-imidazolium tetrafluoroborate (1E-3MI-TFB), used for the coating of a silica capillary enables one to reduce or invert the electroosmotic flow (EOF) in capillary zone electrophoresis. Excellent separations of amino acids and ary lalkanoic acids were obtained. Such separations could not be obtained in a naked capillary in the presence of the cationic surfactants cetyltrimethylammonium bromide (CTAB) or polycationic polymer hexadimethrine bromide (HDB). The results indicate that 1E-3MI-TFB not only modulates the EOF but also acts as a discriminator. Further experiments indicate that the interaction between hydrogen at C-2 carbon of IL and acid drugs plays an important role in the separation.

Copyright information

© Pleiades Publishing, Inc. 2006

Authors and Affiliations

  • T. -F. Jiang
    • 1
    • 2
    • 3
  • Y. -H. Wang
    • 1
    • 2
    • 3
  • Z. -H. Lv
    • 1
    • 2
    • 3
  1. 1.Key Laboratory of Marine Drugs (Ocean University of China)Ministry of EducationChina
  2. 2.Key Laboratory of MarineDrugs of Shangdong ProvinceChina
  3. 3.Marine Drug and Food InstituteOcean University of China QuingdaoChina