Meiotic inactivation of sex chromosomes in mammals
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- Vaskova, E.A., Pavlova, S.V., Shevchenko, A.I. et al. Russ J Genet (2010) 46: 385. doi:10.1134/S1022795410040010
During meiosis, heteromorphic mammalian X and Y chromosomes in males undergo transcription silencing and form a compact structure, the XY body, containing specific modifications of the chromatin. In this review, we consider the dynamics of sex chromosome inactivation and discuss the suggestion that the paternally inherited X-chromosome preserves inactivated state in zygote. This state results from meiotic silencing and is prone to imprinted inactivation, which is observed in mammalian females at early embryogenetic stages.