Russian Journal of Genetics

, Volume 46, Issue 4, pp 385–393

Meiotic inactivation of sex chromosomes in mammals

Authors

  • E. A. Vaskova
    • Institute of Cytology and Genetics, Siberian BranchRussian Academy of Sciences
  • S. V. Pavlova
    • Institute of Cytology and Genetics, Siberian BranchRussian Academy of Sciences
  • A. I. Shevchenko
    • Institute of Cytology and Genetics, Siberian BranchRussian Academy of Sciences
    • Institute of Cytology and Genetics, Siberian BranchRussian Academy of Sciences
Reviews and Theoretical Articles

DOI: 10.1134/S1022795410040010

Cite this article as:
Vaskova, E.A., Pavlova, S.V., Shevchenko, A.I. et al. Russ J Genet (2010) 46: 385. doi:10.1134/S1022795410040010

Abstract

During meiosis, heteromorphic mammalian X and Y chromosomes in males undergo transcription silencing and form a compact structure, the XY body, containing specific modifications of the chromatin. In this review, we consider the dynamics of sex chromosome inactivation and discuss the suggestion that the paternally inherited X-chromosome preserves inactivated state in zygote. This state results from meiotic silencing and is prone to imprinted inactivation, which is observed in mammalian females at early embryogenetic stages.

Copyright information

© Pleiades Publishing, Ltd. 2010