, Volume 46, Issue 4, pp 385-393
Date: 25 Apr 2010

Meiotic inactivation of sex chromosomes in mammals

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Abstract

During meiosis, heteromorphic mammalian X and Y chromosomes in males undergo transcription silencing and form a compact structure, the XY body, containing specific modifications of the chromatin. In this review, we consider the dynamics of sex chromosome inactivation and discuss the suggestion that the paternally inherited X-chromosome preserves inactivated state in zygote. This state results from meiotic silencing and is prone to imprinted inactivation, which is observed in mammalian females at early embryogenetic stages.

Original Russian Text © E.A. Vaskova, S.V. Pavlova, A.I. Shevchenko, S.M. Zakian, 2010, published in Genetika, 2010, Vol. 46, No. 4, pp. 437–447.