Russian Journal of Genetics

, Volume 42, Issue 1, pp 67–71

The effect of methyl supplements during pregnancy on the phenotypic modification of offspring agouti coat color in rats

  • L. A. Prasolova
  • L. N. Trut
  • I. N. Oskina
  • R. G. Gulevich
  • I. Z. Plyusnina
  • E. B. Vsevolodov
  • I. F. Latipov
Animal Genetics

DOI: 10.1134/S1022795406010091

Cite this article as:
Prasolova, L.A., Trut, L.N., Oskina, I.N. et al. Russ J Genet (2006) 42: 67. doi:10.1134/S1022795406010091

Abstract

The effect of methyl supplements to the diet of pregnant homozygous (AAHH) female rats with agouti coat color mated with homozygous (aahh) males on the phenotypic modification of the coat color of their heterozygous offspring (AaHh) has been studied. Comparative morphological analysis of the main parameters of hair that determine coat color, including the total length of hairs of different types and the length of the upper black (eumelanin) and light (pheomelanin) parts of awn hairs has been performed. The pattern of pigment granule distribution among hair layers has been analyzed. The melanin content of the hair has been determined using electron spin resonance (ESR). Although all offspring have a typical agouti coat color (alternating black and light portions of hair), 39% of them have a darker coat color than control and other experimental rats have. The main differences between the offspring with darkened and standard coat colors are accounted for by the ratio between the eumelanin and pheomelanin portions of awn hairs. In darkened offspring, this ratio is significantly higher than in control rats. The possible mechanisms of the phenotypic modification of agouti coat color in experimental animals are discussed.

Copyright information

© Pleiades Publishing, Inc. 2006

Authors and Affiliations

  • L. A. Prasolova
    • 1
  • L. N. Trut
    • 1
  • I. N. Oskina
    • 1
  • R. G. Gulevich
    • 1
  • I. Z. Plyusnina
    • 1
  • E. B. Vsevolodov
    • 2
  • I. F. Latipov
    • 2
  1. 1.Institute of Cytology and Genetics, Siberian DivisionRussian Academy of SciencesNovosibirskRussia
  2. 2.Institute of General Genetics and CytologyAcademy of Sciences of KazakhstanAlmatyKazakhstan

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