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Distribution of polymorphic variants of the GSTP1 gene involved in biotransformation of xenobiotics in Tundra Nenets and Nganasans in comparison to Russians

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Abstract

The first study on the frequencies of polymorphic variants of the GSTP1 gene encoding glutathione-S-transferase P1 in Tundra Nenets and Nganasan populations was performed. The subject of the study was the single nucleotide polymorphisms rs1695 (Ile105Val substitution in the protein sequence) and rs1138272 (Ala114Val substitution) that had previously been shown to be associated with cancer and other multifactorial diseases. The data for Tundra Nenets of the Yamalo-Nenets autonomous okrug, Nganasans of the Taimyr Peninsula, and Russian residents of the Northern Siberia were compared. The frequencies of the mutant 105Val and 114Val variants were 10.8% and 0.8% in Nganasans, 23.7% and 4.8% in Nenets, and 35.8% and 9.1% in Russian population samples, respectively. The differences within all pairs of populations were significant for each allele. These differences may characterize the population-level susceptibility to cancer and other multifactorial diseases.

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References

  1. Trufakin, V.A. and Krivoschekov, S.G., Health condition of Siberian population (medical ecological analysis), Int. J. Circumpolar Health, 2004, vol. 63, no. 2, p. 93.

    Google Scholar 

  2. Leutin, V.P., Osipova, L.P., and Krivoschekov, S.G., Relation between hormonal characteristics of stress and sensorimotor asymmetry of the North Selkups, Fiziol. Chel., 1996, vol. 22, no. 1, p. 131.

    CAS  Google Scholar 

  3. Shishkin, G.S. and Ustyuzhaninova, N.V., Funktsional’noe sostoyanie vneshnego dykhaniya zdorovogo cheloveka (Functional State of External Respiration in Healthy Human), Novosibirsk: Izd. Sib. Otd. Ross. Akad. Nauk, 2012.

    Google Scholar 

  4. Board, P.G. and Menon, D., Glutathione transferases, regulators of cellular metabolism and physiology, Biochim. Biophys. Acta, 2013, vol. 1830, no. 5, p. 3267.

    CAS  PubMed  Google Scholar 

  5. Sheehan, D., Meade, G., Foley, V.M., and Dowd, C.A., Structure, function and evolution of glutathione transferases: implications for classification of non-mammalian members of an ancient enzyme superfamily, Biochem. J., 2001, vol. 360, p. 1.

    CAS  PubMed  Google Scholar 

  6. Hayes, J.D., Flanagan, J.U., and Jowsey, I.R., Glutathione transferases, Annu. Rev. Pharmacol. Toxicol., 2005, vol. 45, p. 51.

    Article  CAS  PubMed  Google Scholar 

  7. Laborde, E., Glutathione transferases as mediators of signaling pathways involved in cell proliferation and cell death, Cell Death Differ., 2010, vol. 17, no. 9, p. 1373. doi 10.1038/cdd.2010.80

    Article  CAS  PubMed  Google Scholar 

  8. Zhang, J., Grek, C., Ye, Z.W., et al., Pleiotropic functions of glutathione S-transferase P, Adv. Cancer Res., 2014, vol. 122, p. 143. doi 10.1016/B978-0-12-4201170.00004-9

    Article  CAS  PubMed  Google Scholar 

  9. Amer, M.A., Ghattas, M.H., and Abo-Elmatty, D.M., and Abou-El-Ela, S.H., Influence of glutathione Stransferase polymorphisms on type-2 diabetes mellitus risk, Genet. Mol. Res., 2011, vol. 10, no. 4, p. 3722. doi 10.4238/2011

    Article  CAS  PubMed  Google Scholar 

  10. Fang, J., Wang, S., Zhang, S., et al., Association of the glutathione S-transferase M1, T1 polymorphisms with cancer: evidence from a meta-analysis, PLoS One, 2013, vol. 8, no. 11, p. e78707. doi 10.1371/journalpone.0078707

    CAS  Google Scholar 

  11. Liu, J.J., Liu, J.L., Zhang, X., et al., A meta-analysis of the association of glutathione S-transferase P1 gene polymorphism with the susceptibility of breast cancer, Mol. Biol. Rep., 2013, vol. 40, no. 4, p. 3203. doi 10.1007/s11033-012-2396-z

    Article  CAS  PubMed  Google Scholar 

  12. Yang, Q., Du, J., and Yao, X., Significant association of Glutathione S-transferase T1 null genotype with prostate cancer risk: a meta-analysis of 26.393 subjects, PLoS One, 2013, vol. 8, no. 1, e53700. doi 10.1371/journalpone.0053700

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  13. Mazzetti, A.P., Fiorile, M.C., Primavera, A., and Lo Bello, M., Glutathione transferases and neurodegenerative diseases, Neurochem. Int., 2015, vol. 82, p. 10. doi 10.1016/jneuint.2015.01.008

    Article  CAS  PubMed  Google Scholar 

  14. Wu, B. and Dong, D., Human cytosolic glutathione transferases: structure, function, and drug discovery, Trends Pharmacol. Sci., 2012, vol. 33, no. 12, p. 656. doi 10.1016/jtips.2012.09.007

    Article  CAS  PubMed  Google Scholar 

  15. Terrier, P., Townsend, A.J., Coindre, J.M., et al., An immunohistochemical study of pi class glutathione Stransferase expression in normal human tissue, Am. J. Pathol., 1990, vol. 137, no. 4, p. 845.

    CAS  PubMed  PubMed Central  Google Scholar 

  16. Rowe, J.D., Nieves, E., and Listowsky, I., Subunit diversity and tissue distribution of human glutathione S-transferases: interpretations based on electrospray ionization-MS and peptide sequence-specific antisera, Biochem. J., 1997, vol. 325, p. 481.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  17. Raijmakers, M.T., Steegers, E.A., and Peters, W.H., Glutathione S-transferases and thiol concentrations in embryonic and early fetal tissues, Hum. Reprod., 2001, vol. 16, no. 11, p. 2445.

    CAS  PubMed  Google Scholar 

  18. Henderson, C.J., McLaren, A.W., and Wolf, C.R., In vivo regulation of human glutathione transferase GSTP by chemopreventive agents, Cancer Res., 2014, vol. 74, no. 16, p. 4378. doi 10.1158/0008-5472.CAN14-0792

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  19. Kodate, C., Fukushi, A., Narita, T., et al., Human placental form of glutathione S-transferase (GST-pi) as a new immunohistochemical marker for human colonic carcinoma, Jap. J. Cancer Res., 1986, vol. 77, no. 3, p. 226.

    CAS  Google Scholar 

  20. Shea, T.C., Kelley, S.L., and Henner, W.D., Identification of an anionic form of glutathione transferase present in many human tumors and human tumor cell lines, Cancer Res., 1988, vol. 48, no. 3, p. 527.

    CAS  PubMed  Google Scholar 

  21. Zhang, R., Kang, K.A., Piao, M.J., et al., Epigenetic alterations are involved in the overexpression of glutathione S-transferase p-1 in human colorectal cancers, Int. J. Oncol., 2014, vol. 45, no. 3, p. 1275. doi 10.3892/ijo.2014.2522

    CAS  PubMed  Google Scholar 

  22. Li, Q.F., Li, Q.Y., Gao, A.R., and Shi, Q.F., Correlation between promoter methylation in the GSTP1 gene and hepatocellular carcinoma development: a metaanalysis, Genet. Mol. Res., 2015, vol. 14, no. 2, p. 6762. doi 10.4238/2015

    Article  CAS  PubMed  Google Scholar 

  23. Litovkin, K., Van Eynde, A., Joniau, S., et al., DNA methylation-guided prediction of clinical failure in high-risk prostate cancer, PLoS One, 2015, vol. 10, no. 6, e0130651. doi 10.1371/journalpone.0130651

    Article  PubMed  PubMed Central  Google Scholar 

  24. Zhang, W., Jiao, H., Zhang, X., et al., Correlation between the expression of DNMT1, and GSTP1 and APC, and the methylation status of GSTP1 and APC in association with their clinical significance in prostate cancer, Mol. Med. Rep., 2015, vol. 12, no. 1, p. 141. doi 10.3892/mmr.2015.3402

    CAS  PubMed  Google Scholar 

  25. Tew, K.D., Glutathione-associated enzymes in anticancer drug resistance, Cancer Res., 1994, vol. 54, no. 16, p. 4313.

    CAS  PubMed  Google Scholar 

  26. Tew, K.D. and Townsend, D.M., Glutathione-s-transferases as determinants of cell survival and death, Antioxid. Redox Signaling, 2012, vol. 17, no. 12, p. 1728. doi 10.1089/ars.2012.4640

    Article  CAS  Google Scholar 

  27. Ali-Osman, F., Akande, O., Antoun, G., et al., Molecular cloning, characterization, and expression in Escherichia coli of full-length cDNAs of three human glutathione s-transferase Pi gene variants: evidence for differential catalytic activity of the encoded proteins, J. Biol. Chem., 1997, vol. 272, no. 15, p. 10004.

    CAS  PubMed  Google Scholar 

  28. Harries, L.W., Stubbins, M.J., Forman, D., et al., Identification of genetic polymorphisms at the glutathione S-transferase Pi locus and association with susceptibility to bladder, testicular and prostate cancer, Carcinogenesis, 1997, vol. 18, no. 4, p. 641.

    CAS  PubMed  Google Scholar 

  29. Zimniak, P., Nanduri, B., Pikua, S., et al., Naturally occurring human glutathione S-transferase GSTP1-1 isoforms with isoleucine and valine in position 104 differ in enzymic properties, Eur. J. Biochem., 1994, vol. 224, no. 3, p. 893.

    Article  CAS  PubMed  Google Scholar 

  30. Hu, X., O’Donnell, R., Srivastava, S.K., et al., Active site architecture of polymorphic forms of human glutathione S-transferase P1-1 accounts for their enantioselectivity and disparate activity in the glutathione conjugation of 7beta,8alpha-dihydroxy-9alpha, 10alpha-oxy-7,8,9,10-tetrahydrobenzo(a)pyrene, Biochem. Biophys. Res. Commun., 1997, vol. 235, no. 2, p. 424.

    Article  CAS  PubMed  Google Scholar 

  31. Sundberg, K., Johansson, A.S., Stenberg, G., et al., Differences in the catalytic efficiencies of allelic variants of glutathione transferase P1-1 towards carcinogenic diol epoxides of polycyclic aromatic hydrocarbons, Carcinogenesis, 1998, vol. 19, no. 3, p. 433.

    Article  CAS  PubMed  Google Scholar 

  32. Ibarrola-Villava, M., Martin-Gonzalez, M., Lazaro, P., et al., Role of glutathione S-transferases in melanoma susceptibility: association with GSTP1 rs1695 polymorphism, Br. J. Dermatol., 2012, vol. 166, no. 6, p. 1176. doi 10.1111/j.1365-2133.2012.10831x

    Article  CAS  PubMed  Google Scholar 

  33. Oliveira, C., Rinck-Junior, J.A., Lourenço, G.J., et al., Assessment of the XPC (A2920C), XPF (T30028C), TP53 (aArg72Pro) and GSTP1 (Ile105Val) polymorphisms in the risk of cutaneous melanoma, J. Cancer Res. Clin. Oncol., 2013, vol. 139, no. 7, p. 1199. doi 10.1007/s00432-013-1430-4

    Article  CAS  PubMed  Google Scholar 

  34. Lesseur, C., Gilbert-Diamond, D., Andrew, A.S., et al., A case-control study of polymorphisms in xenobiotic and arsenic metabolism genes and arsenic-related bladder cancer in New Hampshire, Toxicol. Lett., 2012, vol. 210, no. 1, p. 100. doi 10.1016/jtoxlet.2012.01.015

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  35. Chan, Q.K., Khoo, U.S., Ngan, H.Y., et al., Single nucleotide polymorphism of Pi-class glutathione Stransferase and susceptibility to endometrial carcinoma, Clin. Cancer Res., 2005, vol. 11, no. 8, p. 2981.

    Article  CAS  PubMed  Google Scholar 

  36. Custodio, A.C., Almeida, L.O., Pinto, G.R., et al., GSTP1 Ile105Val polymorphism in astrocytomas and glioblastomas, Genet. Mol. Res., 2010, vol. 9, no. 4, p. 2328. doi 10.4238/vol9-4gmr971

    Article  CAS  PubMed  Google Scholar 

  37. Zendehdel, K., Bahmanyar, S., McCarthy, S., et al., Genetic polymorphisms of glutathione S-transferase genes GSTP1, GSTM1, and GSTT1 and risk of esophageal and gastric cardia cancers, Cancer Causes Control, 2009, vol. 20, no. 10, p. 2031. doi 10.1007/s10552-0099399-7

    Article  PubMed  Google Scholar 

  38. Ma, Y., Wei, X., Han, G., et al., Glutathione S-transferase P1 Ile105Val polymorphism contributes to increased risk of gastric cancer in East Asians, Tumour Biol., 2013, vol. 34, no. 3, p. 1737. doi 10.1007/s13277013-0711-5 l

    Article  CAS  PubMed  Google Scholar 

  39. Schultz, E.N., Devadason, S.G., Khoo, S.K., et al., The role of GSTP1 polymorphisms and tobacco smoke exposure in children with acute asthma, J. Asthma, 2010, vol. 47, no. 9, p. 1049. doi 10.1080/ 02770903. 2010.508856

    Article  CAS  PubMed  Google Scholar 

  40. Hoskins, A., Wu, P., Reiss, S., and Dworski, R., Glutathione S-transferase P1 Ile105val polymorphism modulates allergen-induced airway inflammation in human atopic asthmatics in vivo, Clin. Exp. Allergy, 2013, vol. 43, no. 5, p. 527. doi 10.1111/cea.12086

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  41. Hwang, B.F., Young, L.H., Tsai, C.H., et al., Fine particle, ozone exposure, and asthma/wheezing: effect modification by glutathione S-transferase P1 polymorphisms, PLoS One, 2013, vol. 8, no. 1, p. e52715. doi 10.1371/journalpone.00552715

    CAS  PubMed  Google Scholar 

  42. Harris, M.J., Coggan, M., Langton, L., et al., Polymorphism of the Pi class glutathione S-transferase in normal populations and cancer patients, Pharmacogenetics, 1998, vol. 8, no. 1, p. 27.

    Article  CAS  PubMed  Google Scholar 

  43. Watson, M.A., Stewart, R.K., Smith, G.B., et al., Human glutathione S-transferase P1 polymorphisms: relationship to lung tissue enzyme activity and population frequency distribution, Carcinogenesis, 1998, vol. 19, no. 2, p. 275.

    Article  CAS  PubMed  Google Scholar 

  44. Mishra, D.K., Kumar, A., Srivastava, D.S., and Mittal, R.D., Allelic variation of GSTT1, GSTM1 and GSTP1 genes in North Indian population, Asian Pac. J. Cancer Prev., 2004, vol. 5, no. 4, p. 362.

    PubMed  Google Scholar 

  45. Matsuzawa, D., Hashimoto, K., Hashimoto, T., et al., Association study between the genetic polymorphisms of glutathione-related enzymes and schizophrenia in a Japanese population, Am. J. Med. Genet., Part B, 2009, vol. 150B, no. 1, p. 86. doi 10.1002/ajmgb.30776

    Article  CAS  Google Scholar 

  46. The 1000 genomes project consortium. An integrated map of genetic variation from 1.092 human genomes. Nature, 2012, vol. 491, no. 7422, p. 56. www. 1000genomesorg. doi 101038/nature11632

  47. Akhmadishina, L.Z., Korytina, G.F., Mingazova, S.R., et al., The role of polymorphism of CYP1A1, EPHX1, GSTM1, GSTT1, and GSTP1 genes in occupational chronic bronchitis development, Ekol. Genet., 2005, vol. 3, no. 1, p. 11.

    CAS  Google Scholar 

  48. Korytina, G.F., Akhmadishina, L.Z., Tselousova, O.S., et al., Polymorphism of the genes for antioxidant defense enzymes and their association with the development of chronic obstructive pulmonary disease in the population of Bashkortostan, Russ. J. Genet., 2009, vol. 45, no. 7, p. 848.

    Article  CAS  Google Scholar 

  49. Zusterzeel, P.L., Nelen, W.L., Roelofs, H.M., et al., Polymorphisms in biotransformation enzymes and the risk for recurrent early pregnancy loss, Mol. Hum. Reprod., 2000, vol. 6, no. 5, p. 474.

    Article  CAS  PubMed  Google Scholar 

  50. Dedkov, A.A., Bogomazov, A.D., Ivanov, V.P., et al., Study of connection between polymorphism Ile105Val of the GSTP1 gene and risk of atopic bronchial asthma in children of Kursk oblast, Chel. Ego Zdor., 2011, no. 1, p. 31.

    Google Scholar 

  51. Zhou, L., Zhu, Y.-Y., Zhang, X.-D., et al., Risk effects of GST gene polymorphisms in patients with acute myeloid leukemia: a prospective study, Asian Pac. J. Cancer Prev., 2013, vol. 14, p. 3861.

    Article  PubMed  Google Scholar 

  52. Juronen, E., Tasa, G., Veromann, S., et al., Polymorphic glutathione S-transferases as genetic risk factors for senile cortical cataract in estonians, Invest. Ophthalmol. Visual Sci., 2000, vol. 41, no. 8, p. 2262.

    CAS  Google Scholar 

  53. Ertunc, D., Aban, M., Tok, E.C., et al., GlutathioneS-transferase P1 gene polymorphism and susceptibility to endometriosis, Hum. Reprod., 2005, vol. 20, no. 8, p. 2157.

    Article  CAS  PubMed  Google Scholar 

  54. Fryer, A.A., Bianco, A., Hepple, M., et al., Polymorphism at the glutathione S-transferase GSTP1 locus a new marker for bronchial hyperresponsiveness and asthma, Am. J. Respir. Crit. Care Med., 2000, vol. 161, p. 1437.

    Article  CAS  PubMed  Google Scholar 

  55. Osipova, L.P., Genetic markers of immunoglobulins (Gm system) to assess the migration and cross-breeding in human populations in Northern Siberia, Sib. Ekol. Zh., 1994, vol. 1, no. 2, p. 129.

    Google Scholar 

  56. Korchagina, R.P., Osipova, L.P., Vavilova, N.A., et al., Polymorphisms of the GSTM1, GSTT1, and CYP2D6 xenobiotic biotransformation genes, which are possible risk markers of cancer in populations of indigenous ethnic groups and Russians of North Siberia, Russ. J. Genet. Appl. Res., 2012, vol. 2, no. 1, p. 7.

    Google Scholar 

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Authors and Affiliations

  1. Institute of Cytology and Genetics, Siberian Branch, Russian Academy of Sciences, Novosibirsk, Russia

    R. P. Tiis, L. P. Osipova, D. V. Lichman, L. E. Tabikhanova & T. V. Churkina

  2. Novosibirsk State University, Novosibirsk, Russia

    L. P. Osipova, D. V. Lichman, E. N. Voronina & M. L. Filipenko

  3. Institute of Chemical Biology and Fundamental Medicine, Siberian Branch, Russian Academy of Sciences, Novosibirsk, Russia

    E. N. Voronina & M. L. Filipenko

  4. Institute of Physiology and Fundamental Medicine, Novosibirsk, Russia

    S. G. Krivoschekov

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Original Russian Text © R.P. Tiis, L.P. Osipova, D.V. Lichman, L.E. Tabikhanova, T.V. Churkina, E.N. Voronina, M.L. Filipenko, S.G. Krivoschekov, 2016, published in Fiziologiya Cheloveka, 2016, Vol. 42, No. 2, pp. 112–120.

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Tiis, R.P., Osipova, L.P., Lichman, D.V. et al. Distribution of polymorphic variants of the GSTP1 gene involved in biotransformation of xenobiotics in Tundra Nenets and Nganasans in comparison to Russians. Hum Physiol 42, 214–222 (2016). https://doi.org/10.1134/S036211971602016X

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