, Volume 34, Issue 1, pp 39-44
Date: 18 Jan 2011

Relationship between neurophysiological indices of cognitive processes and MRI characteristics of some brain structures in healthy subjects and patients with schizophrenia

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The relationships between the parameters of waves of auditory event-related potentials (ERPs) in the oddball paradigm and the volumes of the hippocampus, amygdala, and caudate nuclei were analyzed in healthy subjects and patients with schizophrenia. The data obtained suggest that faster mental processes and stronger activation and/or synchronization of the activity of ERP wave generators in healthy subjects correspond to smaller volumes of the structures studied. The structure of the relationships in patients with schizophrenia differed from the normal one; significant correlations were observed with the volume of the caudate nuclei, and more pronounced “normalization” of neurophysiological characteristics was associated with large volumes of these structures.

Original Russian Text © I.S. Lebedeva, Yu.A. Voronkova, L.V. Gubskii, D.A. Kupriyanov, 2008, published in Fiziologiya Cheloveka, 2008, Vol. 34, No. 1, pp. 46–51.