Optics and Spectroscopy

, Volume 107, Issue 6, pp 884–890

Multimodal polarization system for imaging skin cancer

  • E. Salomatina-Motts
  • V. A. Neel
  • A. N. Yaroslavskaya
Optics and Spectroscopy in Biomedical Investigations

DOI: 10.1134/S0030400X0912008X

Cite this article as:
Salomatina-Motts, E., Neel, V.A. & Yaroslavskaya, A.N. Opt. Spectrosc. (2009) 107: 884. doi:10.1134/S0030400X0912008X

Abstract

An optical system is created that is capable of detecting tumor formations in vivo in real time by means of the spectrally resolved polarization imaging of light elastically scattered by tissue and imaging of fluorescence polarization of exogenous fluorophores. The performance characteristics of the system, such as the resolution, field of view, and power density and stability of the radiation, as well as the calibration G factor, are determined. The functionality of the system is tested under clinical conditions. Spectrally resolved signals of elastic scattering and fluorescence polarization images are detected both from the wound surface in vivo and from the bioptic material. The reliability of the method is proven by comparing the results with the data of histological studies.

Copyright information

© Pleiades Publishing, Ltd. 2009

Authors and Affiliations

  • E. Salomatina-Motts
    • 1
    • 2
  • V. A. Neel
    • 1
    • 2
  • A. N. Yaroslavskaya
    • 1
    • 2
    • 3
  1. 1.Wellman Center for PhotomedicineBostonUSA
  2. 2.Massachusetts General HospitalBostonUSA
  3. 3.Department of DermatologyHarvard UniversityBostonUSA