Molecular Biology

, 45:421

Genome-wide association study of allergic diseases in Russians of West Siberia

  • M. B. Freidin
  • E. Yu. Bragina
  • O. S. Fedorova
  • I. A. Deev
  • E. S. Kulikov
  • L. M. Ogorodova
  • V. P. Puzyrev
Genomics. Transcriptomics

DOI: 10.1134/S0026893311020075

Cite this article as:
Freidin, M.B., Bragina, E.Y., Fedorova, O.S. et al. Mol Biol (2011) 45: 421. doi:10.1134/S0026893311020075

Abstract

Genome-wide association studies are currently considered as one of the most powerful tools for establishing the genetic basis of complex diseases. A number of such studies have been carried out for allergic diseases; however, in the Russian population, this analysis has not been performed so far. For the first time, we performed a genome-wide association study of allergic diseases in Russian residents of West Siberia. Two new loci associated with childhood bronchial asthma (20q13.12, rs2425656, P = 1.99 × 10−7; 1q32.1, rs3817222, rs12734001, P = 2.18 × 10−7 and 2.79 × 10−7, respectively) as well as one locus associated with allergic rhinitis (2q36.1, rs1597167, P = 3.69 × 10−7) were identified. Genes located in these loci, YWHAB and PPP1R12B for asthma and KCNE4 for allergic rhinitis, are suggested as new candidate genes for these diseases. It was also found that BAT1 (6p21.33), MAGI2 (7q21.11), and ACPL2 (3q23) are probably common (syntropic) genes of allergic disease and atopic sensitization. It was shown that RIT2 (18q12.3) and FSTL4 (5q31.1) genes can be involved in the control of lung function. The results of the study contribute to the body of data on genetic factors of allergy and expand the list of genes underlying these diseases.

Keywords

genome-wide association study syntropic genes allergic diseases bronchial asthma allergic rhinitis atopic dermatitis atopic sensitization lung function 

Abbreviations

AD

atopic dermatitis

AR

allergic rhinitis

BA

bronchial asthma

CI

confidence interval

GWAS

genome-wide association study

MFD

multifactorial disease

SNP

single nucleotide polymorphism

OR

odds ratio

LF

lung function

TDT

Transmission Disequilibrium Test

Copyright information

© Pleiades Publishing, Ltd. 2011

Authors and Affiliations

  • M. B. Freidin
    • 1
  • E. Yu. Bragina
    • 1
  • O. S. Fedorova
    • 2
  • I. A. Deev
    • 2
  • E. S. Kulikov
    • 2
  • L. M. Ogorodova
    • 2
  • V. P. Puzyrev
    • 1
    • 2
  1. 1.Research Institute of Medical GeneticsRussian Academy of Medical Sciences, Siberian BranchTomskRussia
  2. 2.Siberian State Medical UniversityTomskRussia

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