Molecular Biology

, Volume 40, Issue 4, pp 570–578

Eukaryotic ribosomal proteins: Interactions with their own pre-mRNAs and their involvement in splicing regulation

  • A. V. Ivanov
  • A. A. Malygin
  • G. G. Karpova
Article

DOI: 10.1134/S0026893306040091

Cite this article as:
Ivanov, A.V., Malygin, A.A. & Karpova, G.G. Mol Biol (2006) 40: 570. doi:10.1134/S0026893306040091
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Abstract

This review summarizes data on expression regulation of the eukaryotic ribosomal protein genes at the level of splicing, including data obtained by the authors. In particular, the roles of ribosomal proteins in regulation of the splicing of their own pre-mRNAs are discussed. Special attention is paid to the molecular mechanisms underlying this process and the interactions between the ribosomal proteins and their own pre-mRNAs and mRNAs. In addition, the potential critical consequences resulting from disturbances of the mechanisms regulating synthesis of ribosomal proteins are considered. The special role of autoregulation in maintaining the normal level of ribosomal protein biosynthesis is underlined.

Key words

eukaryotic ribosomal proteinsregulation of gene expressionsplicingRNA-protein interactions

Copyright information

© Pleiades Publishing, Inc. 2006

Authors and Affiliations

  • A. V. Ivanov
    • 1
  • A. A. Malygin
    • 1
  • G. G. Karpova
    • 1
  1. 1.Institute of Chemical Biology and Fundamental Medicine, Siberian DivisionRussian Academy of SciencesNovosibirskRussia