Molecular Biology

, Volume 40, Issue 1, pp 16–19

Time scale of Poxvirus evolution

  • I. V. Babkin
  • S. N. Shchelkunov
Priority Communications

DOI: 10.1134/S0026893306010031

Cite this article as:
Babkin, I.V. & Shchelkunov, S.N. Mol Biol (2006) 40: 16. doi:10.1134/S0026893306010031


Unlike in vertebrates and RNA viruses, the molecular clock has not been estimated so far for DNA viruses. The extended conserved central region (102 kb) of the orthopoxvirus genome and the DNA polymerase gene (3 kb) were analyzed in viruses representing several genera of the family Poxviridae. Analysis was based on the known dating of the variola virus (VARV) transfer from Western Africa to South America and previous data on the phylogenetic relatedness of modern West African and South American isolates of VARV. The mutation accumulation rate was for the first time estimated for these DNA viruses at (0.9–1.2) × 10−6 substitutions per site per year. It was assumed that poxviruses diverged from an ancestor approximately 500,000 years ago to form the recent species and that the ancestor of the genus Orthopoxvirus emerged approximately 300,000 years ago and gave origin to the modern species approximately 14,000 years ago.

Key words

DNA virusesPoxviridaeevolutionmolecular clock

Copyright information

© Pleiades Publishing, Inc. 2006

Authors and Affiliations

  • I. V. Babkin
    • 1
  • S. N. Shchelkunov
    • 1
  1. 1.Vector State Research Center of Virology and BiotechnologyKol’tsovo, Novosibirsk RegionRussia