Complex Systems Biophysics

Biophysics

, Volume 55, Issue 4, pp 610-614

First online:

Nitrites can be reduced in retinal vessels during hypoxia and protect the retina against ischemia and apoptosis

  • G. R. KalamkarovAffiliated withEmanuel Institute of Biochemical Physics, Russian Academy of Sciences
  • , T. S. KonstantinovaAffiliated withEmanuel Institute of Biochemical Physics, Russian Academy of Sciences
  • , A. E. BugrovaAffiliated withEmanuel Institute of Biochemical Physics, Russian Academy of Sciences
  • , T. F. ShevchenkoAffiliated withEmanuel Institute of Biochemical Physics, Russian Academy of Sciences
  • , I. V. TsapenkoAffiliated withHelmholtz Research Institute of Eye Diseases
  • , M. V. ZuevaAffiliated withHelmholtz Research Institute of Eye Diseases
  • , A. N. IvanovAffiliated withHelmholtz Research Institute of Eye Diseases

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Abstract

The possibility and the mechanism of the reduction of nitrites in retinal vessels under acute hypoxia in vivo have been investigated. An experimental model of rat retinal ischemia was elaborated using laser coagulation of retinal vessels. It was demonstrated that vessel thrombosis does not occur if the nitrite concentration in the vessels is increased. It was proposed that, under acute hypoxia, nitrites are reduced to NO, which results in drastic vasodilatation. Considering that the effect takes less than a minute, this reduction cannot be due to hypoxic acidosis but is more likely associated with NO reduction by heme proteins. It was found that increased concentration of nitrites protects the retina from the development of ischemia progress and that preliminary administration of nitrites prevents apoptosis in the retina and a decrease in its photoelectric activity.

Keywords

nitric oxide nitrites ischemia apoptosis eye retina retinal pathologies