Biochemistry (Moscow)

, Volume 78, Issue 1, pp 19–36

Keap1/Nrf2/ARE redox-sensitive signaling system as a pharmacological target

  • N. K. Zenkov
  • E. B. Menshchikova
  • V. O. Tkachev
Review

DOI: 10.1134/S0006297913010033

Cite this article as:
Zenkov, N.K., Menshchikova, E.B. & Tkachev, V.O. Biochemistry Moscow (2013) 78: 19. doi:10.1134/S0006297913010033

Abstract

The redox-sensitive signaling system Keap1/Nrf2/ARE plays a key role in maintenance of cellular homeostasis under stress, inflammatory, carcinogenic, and proapoptotic conditions, which allows us to consider it as a pharmacological target. Here we review the basic regulatory mechanisms of the Keap1/Nrf2/ARE system, key targets for pharmacological intervention, and interconnection of this system with other redox-sensitive transcriptional factors. We also discuss the range of currently available pharmaceuticals. Finally, we promote “indirect” antioxidants as a promising strategy for prevention and treatment of wide range of diseases associated with oxidative stress.

Key words

Nrf2antioxidant-responsive element (ARE)transcription factorspharmaceuticals

Abbreviations

ARE

antioxidant-responsive element

CNC

cap’n’Collar family

Cul3-E3-ligase

Cullin-3-containing ubiquitin-ligase complex E3

Keap1

Kelch-like ECH-associated protein 1

MAPK

mitogen-activated protein kinases

NQO1

NAD(P)H:quinone oxidoreductase 1

Nrf2

NF-E2-bound factor 2

ROS

reactive oxygen species

Copyright information

© Pleiades Publishing, Ltd. 2013

Authors and Affiliations

  • N. K. Zenkov
    • 1
  • E. B. Menshchikova
    • 1
  • V. O. Tkachev
    • 1
    • 2
  1. 1.Scientific Center of Clinical and Experimental MedicineSiberian Branch of the Russian Academy of Medical SciencesNovosibirskRussia
  2. 2.University of Michigan School of MedicineAnn ArborUSA