Biochemistry (Moscow)

, Volume 77, Issue 11, pp 1312–1314

Bacteriolytic activity of human interleukin-2

  • P. A. Levashov
  • S. A. Sedov
  • N. G. Belogurova
  • S. V. Shipovskov
  • A. V. Levashov
Article

DOI: 10.1134/S0006297912110107

Cite this article as:
Levashov, P.A., Sedov, S.A., Belogurova, N.G. et al. Biochemistry Moscow (2012) 77: 1312. doi:10.1134/S0006297912110107

Abstract

In this paper we report the discovery of bacteriolytic activity of an immune system cytokine mediator, interleukin-2. Bacteriolytic activity of interleukin-2 was compared with a well-known bacteriolytic enzyme — chicken egg white lysozyme — by monitoring the lysis of the Gram-negative bacterium Escherichia coli, the Gram-positive coccus Micrococcusluteus, and the Gram-positive spore-forming bacillus Bacillus subtilis. It was found that interleukin-2 has greater specificity to the Gram-negative bacterium E. coli than does lysozyme. In contrast to chicken egg white lysozyme, interleukin-2 does not lyse the Gram-positive coccus M. luteus and the Gram-positive spore-forming bacillus B. subtilis. These results give a new understanding of the biological functions of interleukin-2, a regulatory protein that plays a role in oncological and infectious diseases.

Key words

interleukin-2bacteriolytic activityEscherichia coli

Copyright information

© Pleiades Publishing, Ltd. 2012

Authors and Affiliations

  • P. A. Levashov
    • 1
  • S. A. Sedov
    • 1
  • N. G. Belogurova
    • 1
  • S. V. Shipovskov
    • 1
  • A. V. Levashov
    • 1
  1. 1.Department of ChemistryLomonosov Moscow State UniversityMoscowRussia